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  • The stem cell technology in the field of regenerative medicine is a promising approach to treat serious diseases, injuries, and aging. Stem cells are undifferentiated cells with the ability to self-renew for extended periods of time and the ability to differentiate into specialized types of cells under the appropriate conditions. Stem cells are usually classified as embryonic or adult. Embryonic stem cells are derived from the inner cell mass of the early embryonic blastocyst. The cells of the inner cell mass give rise to all three primary germ layers and germ cells of the developing embryo, and therefore these cells have the potential to differentiate into a wide variety of cell types. Adult stem cells, also called somatic stem cells, are undifferentiated cells found among differentiated cells of a tissue or organ. Compared with embryonic stem cells, adult stem cells have more limited self-renewal and differentiation potential. Based on these characteristics, stem cell therapies hold great promises for the treatment of Parkinson's disease, diabetes, Duchenne muscular dystrophy, and other diseases caused by impaired cell function.

    Small molecules that target specific signaling pathways have been shown to be effective tools for manipulating cell fate, state, and function. They can affect the processes of cell self-renewal, survival, differentiation, migration, and reprogramming. These small molecules can not only be developed as conventional therapeutics to stimulate endogenous cell repair and regeneration in vivo, but can also be useful in generating desired cell types for a variety of applications in vitro.

    Small Molecules for Stem Cell Research

    Amerigo Scientific provides a wide range of research-grade small molecules targeting a variety of signaling pathways for use in stem cell research, regulating stem cell biology by affecting reprogramming, self-renewal, or differentiation.

    Product Name CAS No. Identity Effect*
    VPA 1069-66-5 Histone deacetylase inhibitor Enable reprogramming of human fibroblasts transduced by Oct4 and Sox2
    BIX 01294 935693-62-2 G9a HMTase inhibitor Promote NPC and MEF reprogramming
    RG 108 48208-26-0 DNA MTase inhibitor Enable reprogramming of MEF transduced by Oct4 and Klf4
    PD0325901 391210-10-9 MEK inhibitor Enhance reprogramming of human fibroblasts; stabilize and select true iPSC clones
    A83 01 909910-43-6 ALK4/5/7 inhibitor Enhance reprogramming
    SB 431542 301836-41-9 ALK4/5/7 inhibitor Replace Sox2 and enhance reprogramming; promote differentiation of neural lineage and endothelial cells
    CHIR 99021 252917-06-9 GSK3 inhibitor Enhance reprogramming of keratinocytes transduced by Oct4 and Klf4
    Kenpaullone 142273-20-9 GSK3/CDK inhibitor Replace Klf4 in iPSC generation
    BayK 8644 71145-03-4 L-type calcium channel agonist Enable reprogramming of MEF transduced by Oct4 and Klf4
    Vitamin C 50-81-7 Antioxidant/enzyme cofactor Enhance reprogramming
    Thiazovivin 1226056-71-8 ROCK inhibitor Enhance reprogramming of human fibroblasts
    Y-27632 146986-50-7 ROCK inhibitor Enhance reprogramming
    Apigenin 520-36-5 E-cadherin inducer Enhance reprogramming
    E-616452 446859-33-2 ALK4/5/7 inhibitor Replace Sox2 when combined with VPA
    EI-275 (PP 1) 172889-26-8 Src kinase inhibitor Replace Sox2 when combined with VPA
    Forskolin 66575-29-9 PKA activator Promote hESCs transition toward mESC-like state
    PS 48 1180676-32-7 PDK1 activator Enhance reprogramming of human primary somatic cells
    LY 294002 154447-36-6 PI3K inhibitor Promote endodermal differentiation of hESCs treated with activin A
    Stauprimide 154589-96-5 NME2 inhibitor Induce ESC differentiation
    IDE1 1160927-48-9 Activator of Nodal pathway Induce endoderm differentiation of ESCs
    Indolactam V 90365-57-4 PKC agonist Enhance differentiation of pancreatic progenitors
    StemRegenin 1 1227633-49-9 AhR antagonist Promote the ex vivo expansion of CD34+ cells
    AMD3100 110078-46-1 CXCR4 antagonist Mobilize stem/progenitor cells

    *Annual review of biomedical engineering vol. 13 (2011): 73-90.


    GMP Small Molecules for Stem Cell Therapy Manufacturing

    Amerigo Scientific also provides safe, reliable, and consistent GMP-grade small molecules for the generation of stem cells to ensure the safety of the stem cell therapies. These GMP-grade small molecules are manufactured following relevant sections of ICH Q7 guidelines (Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients), which ensures batch-to-batch consistency, traceability from starting material to final product and animal-free production.

    Product Name CAS No. Identity Effect
    CHIR99021 252917-06-9 GSK-3 inhibitor and WNT pathway activator Enable reprogramming of human somatic cells into iPSCs
    LDN193189 1435934-00-1 Potent and selective ALK2 and ALK3 inhibitor Promote neural induction of hPSCs
    SB431542 301836-41-9 TGF-β1, ALK4 and ALK7 Inhibitor Replace SOX2 in reprogramming of fibroblasts to iPSCs
    XAV939 284028-89-3 Tankyrase Inhibitor Promote cardiomyocyte differentiation from ESCs
    Y-27632 129830-38-2 Selective ROCK inhibitor Increase survival of ESCs and iPSCs undergoing cryopreservation

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