Nucleosides, consisting of a nucleoside and a phosphate, are monomeric units of nucleic acids (DNA and RNA). In vitro, purified nucleosides are protected by protecting groups to create phosphoramidites, which can then be used to synthesize an oligonucleotide and/or to obtain analogues not found in nature. These oligonucleotide fragments generally under 200 base pairs are then connected using various assembly methods to synthesize the target nucleic acid.
Amerigo Scientific offers a collection of building blocks, modified nucleoside derivatives, intermediates and other reagents that meet your oligo synthesis or nucleic acids synthesis needs.
Amerigo Scientific offers triantennary GalNAc (tri-GalNAc) CPG for the synthesis of siRNA-GalNAc conjugates, which show good efficiency and safety for targeted delivery to hepatocytes in vivo.
Amerigo Scientific offers tri-GalNAc azide that can be bound to oligonucleotides via a click reaction. Conjugation using click chemistry has the characteristics of modular, facile, wide scope, stereospecificity, high yields, and few or no byproducts.
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