Diffusion is the main mode of mass transfer in porous particle chromatography. In polydisperse media, the uneven diffusion pathlength between particles of different sizes and shapes leads to slow mass transfer rate, long elution time, and band broadening, resulting in a loss of chromatographic column efficiency. These limitations can be overcome by using spherical monodisperse media with similar diffusion path lengths.

Amerigo Scientific provides monodisperse chromatographic media for high performance liquid chromatography (UPLC and HPLC), process-scale purification, and solid phase extraction (SPE) sample preparation. These media of spherical monodisperse particles are manufactured utilizing world leading technology in an ISO-9001-certified facility for the purification of proteins, enzymes, antibodies, viruses, and other substances.

Developed using unique patented technology, the chromatographic media are characterized by uniform particle size, perfect sphericity, excellent mechanical strength, which give the products advantages in chromatographic applications including high efficiency, robust packaging and repackaging, quality consistency, etc.


  • Rigorous manufacturing process and large-scale production
  • Uniformed particle size and perfectly spherical shape
  • Optimal pore structure
  • Unique selectivity
  • Lower back pressure
  • Less risk for fouling or clogging for longer lifetime
  • Possible to use larger mesh size filters/nets


  • High consistency and repeatability between batches
  • High column efficiency, low plugging risk for frits
  • Better column integrity and efficiency (HETP & asymmetry)
  • High loading capacity
  • Higher resolution
  • Faster mass transfer, more concentrated elution, and less buffer consumption
  • Robust column packing and repacking, long lifetime

Product Range

Silica Chromatography Media

Normal Phase Silica Gels

Ultra-high purity monodisperse silica microspheres

HILIC Silica Gels

A new generation of hydrophilic interaction liquid chromatography media

Reversed Phase Silica Gels

Reversed phase silica gels based on monodisperse UniSil® media

Polymeric Chromatography Media

Reversed Phase Chromatography Resins

Polymeric resins for reversed phase chromatography

Ion Exchange Chromatography Resins

Resins with charged functional groups that attract biomolecules with opposite charges

Hydrophobic Interaction Chromatography Resins

Chemically modified highly crosslinked polymethacrylate resin beads

Protein A Affinity Resins

Rigid, mono-sized polymethacrylate matrices for purification of antibodies

Affinity Chromatography Resins

Immobilized Metal Ion Affinity Chromatography Resins

Resins for purifying proteins based on the affinity of certain amino acids to specific metal ions

Boronic Acid Affinity Chromatography Resins

Affinity media for the selective separation and purification of cis-diol containing compounds

Heparin Affinity Chromatography Resins

Affinity chromatography resins for purification of biological substances

Solid Phase Extraction Sorbents

Monodisperse Solid Phase Extraction Sorbents

Specialty monodisperse microspheres with good chemical stability, broad pH range, and optimized surface functional groups

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