Vitamin C

- Overview
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    Background
    
    Vitamin C, a water-soluble vitamin, typically functions in the prevention and treatment of the common cold, hypersensitivity and viral infection. It has also been used as an auxiliary treatment for patients with cancer [1].
    In CT26 murine colon cancer cells, 100 and 200 μg/ml Vitamin C significantly inhibited tumor cell proliferation. When concentrations of Vitamin C exceeded 200 µg/ml, tumor cells underwent apparent apoptosis. At concentrations of 200, 500 and 1000 µg/ml, Vitamin C markedly induced tumor cell apoptosis, in a dose-dependent manner. In addition, synergistic inhibitory effects of vitamin C (200 µg/ml) and Cisplatin (1 mg/ml) against CT26 tumor cells were observed [1].
    In CT26 tumor-bearing BALB/c mice, tumor volume substantially decreased in the high-dose group (2, 4 and 6 mg during 8 ~ 11, 14 ~ 17 and 20 ~ 23 d after inoculation, respectively). Significant diminution of 4T1 tumor growth could also be observed following low- (1, 2, 3 and 4 mg during 8 ~ 11, 14 ~ 17, 20 ~ 23 and 26 ~ 29 d after inoculation, respectively) and high-dose (2, 4, 6 and 8 mg during 8 ~ 11, 14 ~ 17, 20 ~ 23 and 26 ~ 29 d after inoculation, respectively) Vitamin C treatment [1].
    
    Reference:
    [1]. Wang G, Yin T, Wang Y. In vitro and in vivo assessment of high-dose vitamin C against murine tumors. Experimental and Therapeutic Medicine, 2016, 12(5): 3058-3062.
- Properties
  - Categories
    
    water soluble vitamin
    
    Alternative Name
    
    (R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one
    
    CAS Number
    
    50-81-7
    
    Molecular Formula
    
    C6H8O6
    
    Molecular Weight
    
    176.12
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥12.2 mg/mL in EtOH with ultrasonic; ≥5.8 mg/mL in DMSO; ≥57.9 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]@H](CO)[[email protected]](C(O)=C1O)OC1=O
    
    * For Research Use Only