Type I Collagen

Type I collagen is the most abundant collagen of the human body, and is present in bone, skin, tendon, and other connective tissues. Type I collagen is the major component and the primary determinant of tensile strength of the extracellular matrix and therefore an ideal substrate for tissue-culture to enhance differentiation, adhesion, proliferation, and migration of a variety of cells.

Amerigo Scientific offers collagen solutions used in basic research to clinical or nutraceutical development for the biomedical and health food market. Medical-grade collagen production has been ISO-certified.

Benefits

  • Pure bovine type I collagen in medical or research grade are produced using highly standardized industrial processes.
  • Uniquely long, intact collagen fibers that developed by proprietary process enable the extrusion of ultrathin, elastic and very strong membranes without the addition of stabilizing chemicals.
  • The unique collagen retaining the in vivo-like structure of insoluble collagen fibers has excellent biocompatibility and biodegradability.
  • Our collagen products provide natural signals for better attachment, growth, and differentiation, thereby supporting authentic cell performance and complex tissue formation.

Product Range

  • For Research & Development

Strict monitoring of industrial purification, filtration and manufacturing processes ensures the production of ultrapure biocompatible collagen products. Routine quality control includes chemical, physical, and biological testing as well as microbiological testing (the determination of endotoxin levels) to ensure high quality and safety of products.

Product Name Size Applications
Collagen Cell Carrier multiple sizes available a universal scaffold for adherent primary cells, cell lines and stem cells for in vitro and in vivo use
Collagen Suspension 1 kg; 15 kg ultrapure collagen type I suspension in research grade for applications such as the development of 3D-scaffolds, sponges, and bioinks
Soluble Collagen 20 ml collagen hydrogels for 3D cell culture or thin coating for 2D cell culture
Collagen Bio Tubes multiple sizes available special scaffolds for tube formation, whereat cells can grow inside and outside the tubes

  • For Basic Medical Research

Standardized type I collagen has unique properties such as biocompatibility, biodegradability, and the ability to be sutured, making them suitable for improvement of medical technologies and development of novel therapies.

Safe Raw Materials

Bovine raw material for medical applications is obtained solely from veterinary-controlled herds in countries where BSE risk is negligible. The feed stock is free of genetically modified organisms (GMO-free).

All bovine raw materials are in compliance with DIN EN ISO 22442 for “medical devices utilizing animal tissues and their derivatives”. In accordance with this norm, our collagen is extracted from animals with full traceability and raw materials are strictly separated during all processes to minimize the risk of cross-contamination.

Quality Commitment

All medical grade collagen products are manufactured according to EN ISO 13485 "Medical devices - Quality Management systems" and are oriented to good manufacturing practices (GMP).

Analytical control of medical collagen follows the guidelines of ASTM F2212-02, a standard guide for characterization of type I collagen as starting material for surgical implants and substrates for tissue engineered medical products (TEMPs).

Product Name Size Applications
Collagen Cell Carrier multiple sizes available a mobile cell carrier for tissue engineering and regenerative medicine;
a biological vehicle for cell implantation that can be sutured directly at the implantation site
Collagen Suspension Inquiry a biocompatible coating of medical devices (a Master File documentation has been submitted to the CDRH of FDA)

  • For Food Production

Premium bovine collagen hydrolysate products – highly soluble, tasteless, and convenient for all-purpose nutraceutical use.

Product Name Size Applications
Collagen Hydrolysate 15 kg / bag ideal for food processing with its good digestibility and easy processing features

Publications

A New Bone Substitute Developed from 3D-Prints of Polylactide (PLA) Loaded with Collagen I: An In Vitro Study. Int J Mol Sci. 2017 Nov 29;18(12):2569.

Online Inquiry

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