ChromCore LC Columns for Separating Small Molecules
Amerigo Scientific offers ChromCore columns based on reversed phase (RP), normal phase (NP)/hydrophilic interaction (HILIC), and ion exchange (IEX) chromatographic techniques. The high performance of ChromCore columns is achieved using innovative particle technology, advanced column chemistry, and well-developed manufacturing processes. The separation media in ChromCore columns are based on monodisperse particles with precisely controlled particle size and pore structure, and high mechanical strength, ensuring the high efficiency and consistency. Advanced column chemistry enables ChromCore columns suitable for a wide range of applications in pharmaceutical, chemical, environmental, food and beverage, academic and other fields.
Reversed-phase liquid chromatography is the most widely used type of liquid chromatography (LC) and is well suited for the separation of non-polar and polar compounds, which can be easily couple with mass spectrometry. Amerigo Scientific offers ChromCore reversed-phase LC columns based on the novel monodisperse particle technology. These columns feature excellent mechanical strength, high column efficiency, ideal selectivity, high resolution, and good column-column consistency.
Advanced monodispersed particle technology ensuing the high column efficiency and high mechanical strength
Versatile column chemistries for a broad range of selectivity
Excellent chromatographic peak shape for acidic, basic, and neutral analytes
Low column bleed for mass spectrometry compatibility
Good column-to-column consistency
Column Efficiency
The combination of advanced monodisperse particle technology and innovative chemistry allows ChromCore reversed-phase columns to achieve higher column efficiency compared to competitive products in the market.
Column: ChromCore AQ C18
, 5 μm
Dimension: 4.6x250 mm
Mobile Phase: 60/40 v/v MeCN/D.I. H2O
Flow Rate: 1 mL/min
Temperature: 30°C
Injection:5 μL
Detection: UV 254 nm
Analyte: Naphthalene
Aqueous Compatibility
The unique column chemistry of ChromCore ensures excellent compatibility with the highly aqueous mobile phase.
Columns: ChromCore AQ C18
and ChromCore 120 C18
, 5 μm
Dimension: 4.6x150 mm
Mobile Phase: 10 mM ammonium acetate buffer, pH5.2
Flow Rate: 1 mL/min
Temperature: 30°C
Injection: 5 μL
Detection: UV 254 nm
Analyte: 1.Cytosine; 2. Uracil; 3.Thymine
Protocol:
1. Equilibrate column with the mobile phase for 20 min before testing for 10 min
2. Stop flow for 10 min
3. Repeat "1" and "2" for 10 cycles
Peak Shape
The advanced bonding technique is utilized to greatly reduce the silanol activity, improving the peak shape of basic compounds.
Compared to the conventional silica particle-based C18 column competitor, ChromCore AQ C18
showed significantly enhanced chemical stability under alkaline conditions due to the high pH resistance nature of its base particles and the protection of densely bonded surface.
Stress Condition:
Mobile Phase: 100 mM NaOH
Flow Rate: 1 mL/min
Temperature: 30C
Normal-Phase/HILIC HPLC columns
ChromCore Normal-Phase/HILIC HPLC columns are based on the combination of novel monodispersed particle technology, advanced column chemistry, and well-established column packing process.
Monodispersed, high-purity, porous, spherical silica particles for high column efficiency and mechanical strength
Versatile column chemistries for broad selectivity coverage
Excellent chromatography performance for symmetrical peaks
Good column-to-column consistency
Ion-Exchange Columns
Based on the novel monodispersed particle technology, advanced column chemistry, and well-established column packing method, ChromCore ion-exchange HPLC columns are suited for the separation of cationic and anionic analytes in pharmaceutical, food and beverage, chemical, environmental, consumer products, etc.
Monodispersed, high-purity, porous, spherical silica particles for high column efficiency and mechanical strength
Suitable for separating cationic and anionic analytes
Good column-to-column consistency
Sugar Columns
ChromCore sugar columns are prepared from monodispersed spherical PS/DVB particles by a unique sulfonation process to generate H+, Na+, or Ca2+ forms for separating sugars, sugar alcohols, organic acids, or their mixture.
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