Target and E3 Ligase Assessment
E1 Ubiquitin Activating Enzymes
Recombinant activating enzymes in monomeric and heterodimeric forms
E2 Ubiquitin Conjugating Enzymes
Recombinant E2 enzymes covering the major conjugating enzyme families
E3 Ubiquitin Ligases
Recombinant RING, HECT and RBR family E3 ligases
Target Validation and E3 Ligase Selection
Recombinant CRL complexes, E1 and E1/E2 activity assays, and 24-enzyme E2 profiling panels
Degrader Design and Synthesis
E3 Ligase Ligands and Target Protein Warheads
VHL, CRBN and IAP ligands plus kinase, bromodomain and nuclear receptor warheads, with conjugation handles
PROTAC Linkers
Bifunctional PEG, click chemistry, activated and protected linkers across a range of chain lengths
E3 Ligase Ligand-Linker Conjugates
VHL, CRBN, IAP and MDM2 ligands pre-joined to linkers, ready for warhead conjugation
Biochemical Evaluation
In Vitro Ubiquitination and E3 Ligase Activity Assays
PROTAC and molecular glue ubiquitination kits, customizable E3 activity assays, and gel-based formats
Ubiquitin / Ubiquitin-like Proteins / Mutants
Ubiquitin-like proteins, wild-type and affinity-tagged ubiquitin, lysine-substituted ubiquitin mutants, and other ubiquitin mutants
Proteasomes / Activators / Subunits
20S proteasome, 26S proteasome, their activators, subunits, purification, and activity detection products
Cellular Degradation Assessment
Cellular Ubiquitination Quantification and Confirmation
UbiQuant sandwich assays for target and total ubiquitination, plus UbiTest TUBE pull-down kits
Benchmark Degraders and Chemical Probes
Published degraders, Homo-PROTAC tools, CRBN molecular glues, and a high-affinity VHL pathway probe
Ubiquitin Binding Proteins
Ubiquitin-binding domain probes for enriching ubiquitinated proteins of a specific chain type and for use as recognition elements in chain-type detection
Mechanism and Linkage Analysis
Ubiquitin Linkage Analysis and Ubiquitome Profiling
Linkage-specific UbiTest kits, K48 and K63 ELISAs, di-ubiquitin standards, and mass spectrometry
Ubiquitin Chains
Typical and atypical ubiquitin chains of various lengths, together with kits for capturing and identifying specific chain types
Deubiquitinating Enzymes
USP, OTU, UCH, MJD/Josephin, MINDY, JAMM/MPN+, and other deubiquitinating enzyme families
Preparation
ADC Payloads
DNA damaging agents, tubulin inhibitors, and other cytotoxic agents
ADC Linkers
Cleavable and noncleavable linkers for connecting antibodies to payloads
Drug-linker Conjugates
Conjugates consisting of cytotoxic agents and linkers that can be linked with antibodies
Target Selection
HTS Assay Kits for Drug Discovery
Kits for the validation of anticancer, antiviral, and antibacterial drug targets
Membrane Protein Research
High-purity membrane proteins, membrane protein detergents, extraction kits, and other research tools
Development
Perkit™ Drug Conjugation Kits
Allowing the biomolecule of interest to be coupled to the selected payload by traditional linker chemistry
AqueaTether™ Reagents and Kits
Super-hydrophilic linkers for conjugation of hydrophobic cytotoxic agents with antibodies or proteins
Anti-idiotypic Antibodies
For immunogenicity and pharmacokinetic analysis in antibody-based drug development
IgG Fc Proteins
Recombinant Fc proteins for the development of IgG-based drugs
Nucleases
Salt active nucleases and GMP-grade nucleases for sample cleanup
Anti-payload Antibodies
Antibodies against cytotoxic agents with high affinity for ADC pharmacokinetic analysis
Preparation
Nucleic Acid Synthesis Products
Building blocks, modified nucleoside derivatives, intermediates, and other reagents for nucleic acid synthesis
Messenger RNA
High-quality synthetic mRNA products with great stability that can be efficiently translated into factors or receptors
mRNA Synthesis Enzymes
GMP-grade mRNA synthesis enzymes for the development and manufacture of mRNA therapeutic drugs
Class 2 CRISPR/Cas Enzymes
Cas9, Cas12a, Cas12b, Cas12f, and Cas13 nucleases for gene editing
Nucleases
Salt active nucleases and GMP-grade nucleases for sample cleanup
Viral Vectors
Viral Packaging Systems
Systems for packaging of expression cassette into retroviral or lentiviral particles
AAV Empty Capsids
Well-characterized AAV empty capsids that can be used as reference materials in assays
AAV Antibodies
Antibodies for monitoring and optimizing entire AAV production processes
AAV Titration ELISA Kits
ELISA kits for the determination of full and empty capsids of AAV serotypes
AAV Serotype Testing Panels
Testing panels for the selection of the optimal AAV serotype for specific applications
Non-viral Vectors
Lipids and PEG Derivatives for mRNA Delivery
Lipid materials and PEGylated derivatives that can be used to form lipid nanoparticles for mRNA delivery
Liposomes and Liposome Research Tools
Liposomes, modified liposomes, and other research tools for drug delivery
GalNAc Conjugates for siRNA Delivery
N-acetylgalactosamine (GalNAc) CPG for the synthesis of siRNA-GalNAc conjugates
ZnO Quantum Dots and ZnO2 Nanoparticles
ZnO QDs and ZnO2 NPs with consistency and stability for drug delivery
Stem Cell Therapies
Small Molecules for Stem Cell Research
Research-grade and GMP-grade small molecules for stem cell therapy research and manufacturing
GMP Proteins for Regenerative Medicine
GMP-grade cytokines and growth factors facilitating the development of regenerative medicine
Transfection Reagents for Stem Cell Research
Lipid-based transfection reagents for the transfer of DNA, RNA, protein, or virus into stem cells
Laminin-511 E8 Fragments
Research- and GMP-grade laminin-511 E8 fragments as cell culture substrates for ESCs/iPSCs
Cell Reprogramming Tools
A wide range of tools to simplify cell reprogramming
Non–stem Cell Therapies
Primary Cells
High-purity primary cells with low passages, rigorous characterization
GMP Cytokines for Immune Cell Therapy
GMP-grade cytokines for the development of immune cell therapy
Class 2 CRISPR/Cas Enzymes
CRISPR/Cas9, Cas12a, Cas12b, Cas12f, and Cas13 nucleases for gene editing
Cell Culture Tools
Human Platelet Lysate
Research-grade and GMP-grade human platelet lysate products for cell growth and proliferation.
Magnetic Cell Separation
Magnetic beads, kits, and other tools used to isolate target cells directly from samples
Non-magnetic Cell Separation
Non-magnetic beads, buffer, kits, and consumables for positive and negative cell isolation
GMP Serum-free Cell Freezing Media
GMP-grade serum-free cell freezing media for cryopreservation of cell lines, primary cells, etc.
Bioreactors
Bioreactors of different sizes and functions to meet different culture needs
Cell Processing Systems
High-performance instruments for cell harvesting, cell filling, and other processing
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