Name: Y-27632
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Y-27632 is a specific inhibitor of Rho-associated kinases (ROCK) family with Ki values of 0.22 μM and 0.30 μM for ROCK1 and ROCK2, respectively.
    Y-27632 has shown selectivity of inhibition by comparing their Ki values for other Rho effector kinases, citron kinase and PKN, as well as PKCα. The Ki values of Y-27632 for citron kinase and PKN are least 20-fold higher, and Ki values for PKCα are about 200-fold higher than those for ROCK kinases. In addition, Y-27632 has been reported to inhibit ROCK1 and ROCK2 by competing with ATP for binding to the kinase in HeLa cells. Besides, Y-27632 has also shown the inhibition of stress fibers in Swiss 3T3 cells when the concentration of Y-27632 is 10 μM [1].
    
    [1] Ishizaki T1, Uehata M, Tamechika I, Keel J, Nonomura K, Maekawa M, Narumiya S. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83.
- Properties
  - Alternative Name
    
    4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
    
    CAS Number
    
    146986-50-7
    
    Molecular Formula
    
    C14H21N3O
    
    Molecular Weight
    
    247.34
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥24.7 mg/mL in DMSO; insoluble in Chloroform
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Haiyang Yu, Shan Lu, et al. "TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli." bioRxiv. March 29, 2020.
    2. Dakhama A, Al Mubarak R, et al. "Tollip Inhibits ST2 Signaling in Airway Epithelial Cells Exposed to Type 2 Cytokines and Rhinovirus." J Innate Immun. 2019 Mar 29:1-13. PMID:30928973
    3. Zhou N, Lee JJ, et al. "Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension." Cell Physiol Biochem. 2017 Nov 23;44(2):701-715. PMID:29169155
    4. Pazhoohan S, Raoufy MR, et al. "Effect of Rho-kinase inhibition on complexity of breathing pattern in a guinea pig model of asthma." PLoS One. 2017 Oct 31;12(10):e0187249. PMID:29088265
    5. GUANGQI ZHOU, XINMEI LIU, et al. "Homeobox B4 inhibits breast cancer cell migration by directly binding to StAR-related lipid transfer domain protein 13." ONCOLOGY LETTERS,August 3, 2017.
    6. Wang E, Wang D, et al. "Growth of hollow cell spheroids in microbead templated chambers." Biomaterials. 2017 Oct;143:57-64. PMID:28763630
    7. Jones BC, Kelley LC, et al. "Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior." Mol Cancer Res. 2017 Jun;15(6):670-682. PMID:28235899
    8. Lamborn IT, Jing H, et al. "Recurrent rhinovirus infections in a child with inherited MDA5 deficiency." J Exp Med. 2017 Jul
    3;214(7):1949-1972. PMID:28606988
    9. Wang Y, Gunasekara DB, et al. "A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium." Biomaterials. 2017 Jun;128:44-55. PMID:28288348
    10. Jones BC, Kelley LC, et al. "Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior." Mol Cancer Res. 2017 Feb 24. PMID:28235899
    11. Chan W, Akhbanbetova A, et al. "Topical delivery of a Rho-kinase inhibitor to the cornea via mucoadhesive film." Eur J Pharm Sci. 2016 May 16. PMID:27196964

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Y-27632

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