UniMab® Protein A Affinity Resins

Products List

UniMab® Protein A Affinity resins are designed to raise the purification efficiency of monoclonal antibodies (mAb) and recombinant Fc fragment proteins. The resins are based on rigid, mono-sized polymethacrylate matrices with good surface hydrophilicity, minimal non-specific binding and high mechanical strength for fast flow operations. With excellent FC binding selectivity and base stability, UniMab® Protein A Affinity resins have proven its strong properties in many successful applications including bioprocess purification of mAb-drugs in phase III.

Products

Product Name	Cat. No.	Particle Diameter	Pore Size	Size
UniMab 50	17010-050100	50 μm		30ml; 100ml; 500ml; 1L; 10L

Highlights

Suitable for columns with higher bed height
High dynamic binding capacity (DBC) and high recovery yield
Minimal non-specific binding
Superior alkaline stability
High reproducibility
Low concentration host cell protein (HCP) and low level of protein A leachate

Features

Matrix	Mono-sized Polymethacrylate
Ligand	Engineered rProtein A
Particle size, µm	50
Loading, mg human IgG/ml packing (4 min residence time)	>35
Maximum pressure, psi (bar, MPa)	116 (8,0.8)
Maximum flow rate, cm/h	800
Protein A leachate	< 5 ng/ml
pH stable range	3-12
CIP cleaning	0.1-0.5M NaOH
Temperature, °C	4-40
Storage	20% Ethanol, 2-8 °C

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