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  • Cell therapy is a therapeutic method that uses cells to regenerate the function of non-/loss-function tissues or cells. The stem cell- and non–stem cell-based unicellular or multicellular therapies can be developed to treat various diseases, especially those that are difficult to cure. There are three sources of cells for therapeutic purposes, including autologous cells, allogeneic cells, and xenogeneic cells. Depending on the nature of the disease and target tissue, cell therapy requires special tools and manipulations for cellular genetic engineering and cell delivery.

    The use of cytokines and growth factors is critical to ensure effective cell therapy. Cytokines are low molecular weight proteins that play key roles in cell signaling, including chemokines, interferons, interleukins, lymphokines, and tumor necrosis factors. Cytokines are produced by a variety of cells, including immune cells, endothelial cells, fibroblasts, and various stromal cells. Growth factors are proteins that affect cell growth. Various cellular activities are affected by growth factors. Cytokines and growth factors are essential for cell expansion, health, function, and immune stimulation. In regenerative medicine, stem cells have additional reliance on these factors for directed differentiation into the appropriate terminal cell type. In immune cell therapies, cytokines are required for in vitro expand of immune cells and persistence in delivered cell therapeutic doses.

    The development of cell therapy progress into clinical trial phase, and transition from research-grade to GMP-grade cytokines is required. Amerigo Scientific offers GMP-grade proteins to facilitate the development of cell therapies. These proteins are manufactured following relevant regulatory guidelines to ensure consistency, safety, and traceable animal-free biological activity.

    GMP Cytokines for Immune Cell Therapy

    Immune cell therapy is a treatment that enhances the immune response by externally delivering cells with the desired function. It can reinvigorate pre-existing immune responses in the body, and drive new immune responses to fight disease. The response to immune cell therapy typically involves the activation and collaboration of multiple immune cell types, including antigen-presenting cells, T lymphocytes (T cells), and natural killer (NK) cells. T cell therapy has emerged as the most advanced within immune cell therapies. In the manufacture of immune cell therapy, cytokines play a key role in the activation and expansion of immune cells and in the selection/polarization in subpopulations.

    Amerigo Scientific offers GMP-grade cytokines that are important in the induction and modulation of an array of immune responses, facilitating the development of immune cell therapy.

    GMP Protein Source DMF Filed
    IFN-gamma E.coli Yes
    IL-1 beta E.coli  
    IL-2 E.coli Yes
    IL-3 E.coli  
    IL-4 E.coli Yes
    IL-6 E.coli Yes
    IL-7 E.coli Yes
    IL-10 E.coli Yes
    IL-15 E.coli Yes
    IL-21 E.coli  
    TNF-alpha E.coli  

    GMP Cytokines and Growth Factors for Regenerative Medicine

    Stem cells play an important role in regenerative medicine by providing the way to repopulate organs damaged by disease due to their ability to self-renew and to regenerate cells of diverse lineages within the tissue in which they reside. Amerigo Scientific provides a wide range of GMP-grade cytokines and growth factors that guide cellular differentiation and regeneration, facilitating the development of regenerative medicine.

    GMP Protein Source DMF Filed
    Activin A CHO cells Yes
    Betacellulin E.coli Yes
    BDNF E.coli  
    BMP-2 CHO cells  
    BMP-4 E.coli  
    EGF E.coli Yes
    FGF basic/FGF2/bFGF E.coli Yes
    Flt-3 Ligand/FLT3L E.coli Yes
    GDF-8/Myostatin NS0 cells  
    GDNF NS0 cells  
    GM-CSF E.coli  
    HGF NS0 cells  
    IGF-I/IGF-1 E.coli Yes
    KGF/FGF-7 E.coli  
    M-CSF E.coli  
    Noggin Fc Chimera NS0 cells  
    PDGF-AA E.coli  
    PDGF-BB E.coli  
    SCF/c-kit Ligand E.coli Yes
    Sonic Hedgehog/Shh (C24II) E.coli  
    Sonic Hedgehog E.coli  
    TGF-beta 1 CHO cells Yes
    Thrombopoietin E.coli Yes
    VEGF E.coli Yes
    Wnt-3a CHO cells  

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