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    • Membrane proteins are large biological molecules that are embedded in or attached to the membrane of a cell or an organelle inside the cell. Membrane proteins are key players in biological processes, responsible for the transport of molecules into and out of cells, the maintenance of the electrical potential difference across the membrane necessary for ion conduction and active transport, the sensing and transduction of intracellular and extracellular signals, the coordination of intracellular signaling, and cell adhesion.

    Mutations in membrane proteins have a wide range of effects, some of which are related to the properties of the proteins. Missense mutations (also called nonsynonymous mutations) may disrupt the native structure of a protein by causing steric clashes or affecting primary, secondary and tertiary structures of the protein. In addition, missense mutations may disrupt protein-protein or protein-membrane interactions. The missense mutations in signal peptides may affect protein trafficking and embedding into the membrane. Many diseases are caused by mutations in membrane proteins, and in particular mutations that disrupt the folding or assembly of membrane proteins are thought to be a major cause of human diseases.

    Product Range

    Amerigo Scientific provides membrane proteins extracted from a large number of documented high-quality tissues using proprietary isolation techniques. The isolation method starts with whole tissue homogenate and protects proteins during the isolation and storage processes, thus ensuring the highest quality of each product. The membrane proteins are stored in a buffer with protease inhibitor cocktail.

    These membrane protein lysates have been tested for quality on western blot. Running on SDS-PAGE gels with our membrane protein products yields sharp bands spanning a wide range of sizes without smearing. Our membrane proteins are useful tools in the field of proteomics to accelerate gene expression analysis by identifying disease-specific membrane proteins and genes. Our products are cost effective and save valuable time for life science research and drug discovery.

    A Large Selection of Tissue Membrane Proteins

    Autoimmune Diseases Cancers
    Metabolic Diseases Neurodegenerative Diseases
    Liver Cirrhosis Normal Tissues

    Product Features

    • ISO 13485:2016 & ISO 9001:2015 certified
    • Extensive quality control procedures for high-quality products
    • Ready-to-use membrane proteins for proteomics research
    • Decontamination of polysaccharide, proteoglycan, RNase, and genomic DNA

    Product Applications

    Our membrane protein products can be used in 2D-PAGE and LC-MS/MS to facilitate the discovery of biomarkers. In addition, our products can be used in immunoprecipitation assays to study protein-protein interactions and can be utilized in enzyme activity assays.

    • Electrophoresis and western blot
    • Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
    • Immunoprecipitation
    • Enzymatic activity assays

    Product List

    Autoimmune Diseases

    Disease Origin Product Description Donor Information
    Lupus Disease Lupus: Kidney Membrane Protein – Lupus: Kidney Female: 36 years old, 1 donor

    Cancers

    Disease Origin Product Description Donor Information
    Adenocarcinoma Colon Membrane Protein – Human Tumor Tissue: Colon Female: 61 years old, 1 donor
    Adenocarcinoma Gallbladder Membrane Protein – Human Tumor Tissue: Gallbladder Male: 48 years old, 1 donor
    Adenocarcinoma Rectum Membrane Protein – Human Tumor Tissue: Rectum Male: 51 years old, 1 donor
    Adenocarcinoma Small Intestine Membrane Protein – Human Tumor Tissue: Small Intestine Male: 68 years old, 1 donor
    Adenocarcinoma Stomach Membrane Protein – Human Tumor Tissue: Stomach Male: 60 years old, 1 donor
    Serous cystic adenoma Ovary Membrane Protein – Human Tumor Tissue: Ovary Female: 54 years old, 1 donor
    Thymoma Thymus Membrane Protein – Human Tumor Tissue: Thymus Female: 34 years old, 1 donor
    Capillary Hemangioma Spleen Membrane Protein – Human Tumor Tissue: Spleen Male: 40 years old, 1 donor
    Hepatocystic Carcinoma Liver Membrane Protein – Human Tumor Tissue: Liver Female: 45 years old, 1 donor
    Invasive Ductal Carcinoma Brain Membrane Protein – Human Tumor Tissue: Brain Female: 36 years old, 1 donor
    Invasive Ductal Carcinoma Breast Membrane Protein – Human Tumor Tissue: Breast Female: 71 years old, 1 donor
    Lung Cancer Lung Membrane Protein – Human Tumor Tissue: Lung Male: 64 years old, 1 donor
    Neoplasia Prostate Prostate Membrane Protein – Human Tumor Tissue: Prostate Male: 77 years old, 1 donor
    Melanoma Melanoma Membrane Protein – Human Tumor Tissue: Melanoma Male: 83 years old, 1 donor
    Melanoma Skin Membrane Protein – Human Tumor Tissue: Skin Male: 25 years old, 1 donor
    Osteosarcoma Bone Membrane Protein – Human Tumor Tissue: Bone Female: 49 years old, 1 donor
    Pancreatic Cancer Pancreas Membrane Protein – Human Tumor Tissue: Pancreas Female: 63 years old, 1 donor
    Renal Cell Carcinoma Kidney Membrane Protein – Human Tumor Tissue: Kidney Male: 37 years old, 1 donor
    Seminoma Testis Membrane Protein – Human Tumor Tissue: Testis Male: 30 years old, 1 donor
    Squamous Cell Carcinoma Esophagus Membrane Protein – Human Tumor Tissue: Esophagus Male: 57 years old, 1 donor
    Disease Origin Product Description Donor Information
    Hodgkin's Lymphoma Lymphoma Membrane Protein – Human Tumor Tissue: Lymphoma Female: 62 years old, 1 donor
    Non-Hodgkin's Lymphoma Lymphoma Membrane Protein – Human Tumor Tissue: Lymphoma Male: 35 years old, 1 donor
    Non-Hodgkin's Lymphoma Lymphoma Membrane Protein – Human Tumor Tissue: Lymphoma Male: 67 years old, 1 donor
    Disease Origin Product Description Donor Information
    Tumor A431 Cell Line Membrane Protein – Human Tumor Cell Line: A431 Inquiry
    Tumor Hela Cell Line Membrane Protein – Human Tumor Cell Line: Hela Inquiry
    Tumor Jurkat Cell Line Membrane Protein – Human Tumor Cell Line: Jurkat Inquiry
    Tumor K 562 Cell Line Membrane Protein – Human Tumor Cell Line: K 562 Inquiry
    Tumor MCF 7 Cell Line Membrane Protein – Human Tumor Cell Line: MCF 7 Inquiry
    Tumor Raji Cell Line Membrane Protein – Human Tumor Cell Line: Raji Inquiry

    Metabolic Diseases

    Disease Origin Product Description Donor Information
    Diabetes Pancreas Membrane Protein – Diabetic Disease: Pancreas Inquiry
    Diabetes Skeletal Muscle Membrane Protein – Diabetic Disease: Skeletal Muscle Female: 64 years old, 1 donor

    Neurodegenerative Diseases

    Disease Origin Product Description Donor Information
    Alzheimer's Disease Brain: Amygdala Membrane Protein – Alzheimer’s Disease: Brain: Amygdala Male: 65 years old, 1 donor
    Alzheimer's Disease Brain: Temporal Lobe Membrane Protein – Alzheimer’s Disease: Brain: Temporal Lobe Male: 87 years old, 1 donor
    Alzheimer's Disease Brain: Hippocampus Membrane Protein – Alzheimer’s Disease: Brain: Hippocampus Female: 93 years old, 1 donor

    Liver Cirrhosis

    Disease Origin Product Description Donor Information
    Liver Cirrhosis Liver Membrane Protein – Liver Cirrhosis: Liver Inquiry
    Liver Cirrhosis Pancreas Membrane Protein – Liver Cirrhosis: Pancreas Inquiry

    Normal Tissues

    Donor Status Origin Product Description Donor Information
    Normal Adipose Membrane Protein – Human Adult Normal Tissue: Adipose Male: 75 years old, 1 donor
    Normal Adrenal Membrane Protein – Human Adult Normal Tissue: Adrenal Male: 57 years old, 1 donor
    Normal Blood Vessel: Artery Membrane Protein – Human Adult Normal Tissue: Blood Vessel: Artery Inquiry
    Normal Bladder Membrane Protein – Human Adult Normal Tissue: Bladder Male: 66 years old, 1 donor
    Normal Brain Membrane Protein – Human Adult Normal Tissue: Brain Male: 66 years old, 1 donor
    Normal Brain: Cerebellum (right) Membrane Protein – Human Adult Normal Tissue: Brain: Cerebellum (right) Inquiry
    Normal Brain: Cerebellum (left) Membrane Protein – Human Adult Normal Tissue: Brain: Cerebellum (left) Female: 60 years old, 1 donor
    Normal Brain: Cerebral Cortex Membrane Protein – Human Adult Normal Tissue: Brain: Cerebral Cortex Male: 22 years old, 1 donor
    Normal Brain: Cerebral Meninges Membrane Protein – Human Adult Normal Tissue: Brain: Cerebral Meninges Male: 82 years old, 1 donor
    Normal Brain: Frontal Lobe Membrane Protein – Human Adult Normal Tissue: Brain: Frontal Lobe Male: 22 years old, 1 donor
    Normal Brain: Occipital Lobe Membrane Protein – Human Adult Normal Tissue: Brain: Occipital Lobe Male: 66 years old, 1 donor
    Normal Brain: Thalamus Membrane Protein – Human Adult Normal Tissue: Brain: Thalamus Male: 75 years old, 1 donor
    Normal Brain: Temporal Lobe Membrane Protein – Human Adult Normal Tissue: Brain: Temporal Lobe Male: 66 years old, 1 donor
    Normal Brain: Amygdala Membrane Protein – Human Adult Normal Tissue: Brain: Amygdala Male: 22 years old, 1 donor
    Normal Brain: Hippocampus Membrane Protein – Human Adult Normal Tissue: Brain: Hippocampus Male: 82 years old, 1 donor
    Normal Brain: Tonsilla Cerebelli Membrane Protein – Human Adult Normal Tissue: Brain: Tonsilla Cerebelli Male: 66 years old, 1 donor
    Normal Brain: Pituitary Membrane Protein – Human Adult Normal Tissue: Brain: Pituitary Male: 77 years old, 1 donor
    Normal Brain Membrane Protein – Monkey (Cynomolgus) Normal Tissue: Brain Female: 3.2 years old, 1 donor
    Normal Brain Membrane Protein – Monkey (Rhesus) Normal Tissue: Brain Female: 4.5 years old, 1 donor
    Normal Brain Membrane Protein – Mouse Normal Tissue: Brain Male: 8 weeks old, 2 donors
    Normal Breast Membrane Protein – Human Adult Normal Tissue: Breast inquiry
    Normal Stomach: Cardia Membrane Protein – Human Adult Normal Tissue: Stomach: Cardia Male: 66 years old, 1 donor
    Normal Colon Membrane Protein – Human Adult Normal Tissue: Colon Female: 42 years old, 1 donor
    Normal Colon Ascending Membrane Protein – Human Adult Normal Tissue: Colon Ascending Male: 87 years old, 1 donor
    Normal Colon descending Membrane Protein – Human Adult Normal Tissue: Colon descending Inquiry
    Normal Stomach: Corpus Membrane Protein – Human Adult Normal Tissue: Stomach: Corpus Inquiry
    Normal Uterus: Corpus Membrane Protein – Human Adult Normal Tissue: Uterus: Corpus Female: 56 years old, 1 donor
    Normal Diaphragm Membrane Protein – Human Adult Normal Tissue: Diaphragm Male: 57 years old, 1 donor
    Normal Small Intestine: Duodenum Membrane Protein – Human Adult Normal Tissue: Small Intestine: Duodenum Female: 70 years old, 1 donor
    Normal Epididymis Membrane Protein – Human Adult Normal Tissue: Epididymis Inquiry
    Normal Esophagus Membrane Protein – Human Adult Normal Tissue: Esophagus Male: 66 years old, 1 donor
    Normal Stomach: Fundus Membrane Protein – Human Adult Normal Tissue: Stomach: Fundus Male: 66 years old, 1 donor
    Normal Uterus: Fundus Membrane Protein – Human Adult Normal Tissue: Uterus: Fundus Inquiry
    Normal Gallbladder Membrane Protein – Human Adult Normal Tissue: Gallbladder Male: 62 years old, 1 donor
    Normal Heart Membrane Protein – Human Adult Normal Tissue: Heart inquiry
    Normal Heart: Ventricle (left) Membrane Protein – Human Adult Normal Tissue: Heart: Ventricle (left) Female: 21 years old, 1 donor
    Normal Heart: Atrium (left) Membrane Protein – Human Adult Normal Tissue: Heart: Atrium (left) Female: 76 years old, 1 donor
    Normal Heart: Atrium (right) Membrane Protein – Human Adult Normal Tissue: Heart: Atrium (right) Female: 76 years old, 1 donor
    Normal Heart Membrane Protein – Monkey (Rhesus) Normal Tissue: Heart Female: 4.5 years old, 1 donor
    Normal Small Intestine: Ileum Membrane Protein – Human Adult Normal Tissue: Small Intestine: Ileum Male: 50 years old, 1 donor
    Normal Small Intestine: Jejunum Membrane Protein – Human Adult Normal Tissue: Small Intestine: Jejunum Inquiry
    Normal Kidney Membrane Protein – Human Adult Normal Tissue: Kidney Inquiry
    Normal Liver Membrane Protein – Human Adult Normal Tissue: Liver Male: 26 years old, 1 donor
    Normal Liver: Left Lobe Membrane Protein – Human Adult Normal Tissue: Liver: Left Lobe Male: 77 years old, 1 donor
    Normal Lung Membrane Protein – Human Adult Normal Tissue: Lung Male: 24 years old, 1 donor
    Normal Lung: Left Upper Lobe Membrane Protein – Human Adult Normal Tissue: Lung: Left Upper Lobe Female: 70 years old, 1 donor
    Normal Lymph Node Membrane Protein – Human Adult Normal Tissue: Lymph Node Inquiry
    Normal Ovary Membrane Protein – Human Adult Normal Tissue: Ovary Inquiry
    Normal Pancreas Membrane Protein – Human Adult Normal Tissue: Pancreas Male: 72 years old, 1 donor
    Normal Parathyroid Membrane Protein – Human Adult Normal Tissue: Parathyroid Female: 80 years old, 1 donor
    Normal Peripheral Blood Leukocyte Membrane Protein – Human Adult Normal Tissue: Peripheral Blood Leukocyte Male: 46 years old, 1 donor
    Normal Placenta Membrane Protein – Human Adult Normal Tissue: Placenta Female: 1 donor
    Normal Prostate Membrane Protein – Human Adult Normal Tissue: Prostate Male: 76 years old, 1 donor
    Normal Stomach: Pylorus Membrane Protein – Human Adult Normal Tissue: Stomach: Pylorus Male: 26 years old, 1 donor
    Normal Rectum Membrane Protein – Human Adult Normal Tissue: Rectum Female: 83 years old, 1 donor
    Normal Salivary Gland Membrane Protein – Human Adult Normal Tissue: Salivary Gland Male: 66 years old, 1 donor
    Normal Skeletal Muscle Membrane Protein – Human Adult Normal Tissue: Skeletal Muscle Male: 24 years old, 1 donor
    Normal Skin Membrane Protein – Human Adult Normal Tissue: Skin Male: 31 years old, 1 donor
    Normal Small Intestine Membrane Protein – Human Adult Normal Tissue: Small Intestine Male: 56 years old, 1 donor
    Normal Spinal Cord Membrane Protein – Human Adult Normal Tissue: Spinal Cord Male: 28 years old, 1 donor
    Normal Spleen Membrane Protein – Human Adult Normal Tissue: Spleen Male: 78 years old, 1 donor
    Normal Stomach Membrane Protein – Human Adult Normal Tissue: Stomach Inquiry
    Normal Testis Membrane Protein – Human Adult Normal Tissue: Testis Male: 72 years old, 1 donor
    Normal Thymus Membrane Protein – Human Adult Normal Tissue: Thymus Female: 74 years old, 1 donor
    Normal Thyroid Membrane Protein – Human Adult Normal Tissue: Thyroid Male: 59 years old, 1 donor
    Normal Tonsil Membrane Protein – Human Adult Normal Tissue: Tonsil Male: 75 years old, 1 donor
    Normal Trachea Membrane Protein – Human Adult Normal Tissue: Trachea Male: 75 years old, 1 donor
    Normal Uterus Membrane Protein – Human Adult Normal Tissue: Uterus Inquiry
    Normal Vagina Membrane Protein – Human Adult Normal Tissue: Vagina Female: 68 years old, 1 donor
    Normal Whole Eye Membrane Protein – Human Adult Normal Tissue: Whole Eye Male: 44 years old, 1 donor

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