• Amerigo Scientific Instrument
  • Amerigo Scientific offers MagPurix series of fully automated sample preparation system for the fast, high-purity, high-yield purification of nucleic acids from a wide range of sample types. The features of MagPurix instruments include a compact, user friendly and intuitive interface, pre-loaded protocols with free upgrades, and a full kits and samples traceability system with end-run complete report in compliance with 21 CFR part 11 regulation. Using our MagPurix instrument can simplify sample preparation to minimize hands-on time, processing errors, and purification variability.

    MagPurix Magnetic Bead Extraction Technology

    MagPurix utilizes the advanced magnetic bead-based nucleic acid extraction technology to achieve true automation of nucleic acid purification from sample to result. The purification process of MagPurix consisted of lysis, binding, washing, and elution steps. The patented liquid handling system of MagPurix ensures better purification efficiency of lysis and elution, and minimizes the residues of magnetic beads and alcohol in the final eluted product.

    Specification of MagPurix Automated Systems

    Instrument MagPurix 12 EVO MagPurix 24 EVO MagPurix 12 N.E.O.
    Dimension (WxDxH) 62.3 x 63.5 x 60.9 cm 91.5 x 66.5 x 60.4 cm 44 x 56 x 54 cm
    Weight 70 kg 100 kg 55 kg
    Power Supply 100 - 240 V AC +/- 10% , 50 / 60Hz +/- 5% 100 - 230 V AC
    Display 7-inch color Touch Panel 8-inch color Touch Panel
    Connectivity LIMS Connectivity Bi- directional LIS Connectivity
    Sample Volume 100 µl -2 ml (maximum to 10 ml sample with pre-treatment) 100 µl -2 ml (up to 15 ml for cfDNA)
    Elution Volume 20-300 µl 50-300 µI
    Processing Time 30-180 min/run
    (protocol dependent)
    20-75 min/run
    (protocol dependent)
    Processing Capability 1-12 samples/run 1-24 samples/run 1-12 samples/run
    Sample Type Whole blood, buffy coat, leukocytes, plasma, serum, FFPE, fresh/frozen tissue, culture cells, saliva, sputum, bacterial cells, swabs, stool, urine, forensics and other biological samples
    Target of Purification Genomic DNA, total viral nucleic acid, bacterial DNA, cfDNA, ctDNA
    Real-Time Video Recorder Automatic video recording during entire extraction process  
    UV Contamination Built-in UV lamp decontamination  
    Door Sensor/ Safety Lock
    Consumable Fixing Lock  
    Appearance MagPurix 12 EVO MagPurix 24 EVO MagPurix 12 N.E.O.

    MagPurix 12/24 EVO

    Product Name Description
    MagPurix 12 EVO 1-12 simultaneously biological samples
    MagPurix 24 EVO 1-24 simultaneously biological samples

    Key Features of MagPurix 12/24 EVO

    • Accurate and reliable solutions for the isolation of nucleic acids from a variety of samples such as whole blood, serum, plasma, swabs, and tissue
    • The extracted high-quality nucleic acids that can be used for any downstream application such as qPCR, NGS, etc.
    • Embedded video recording system for sample records and technical support
    • Instrument real-time self-calibration reducing routine maintenance work

    Traceability of MagPurix 12/24 EVO

    When using MagPurix 12/24 EVO, the user logs in with ID, and scans the barcode on the sample tube, cartridge, and elution tube. The built-in camera automatically monitors the nucleic acid extraction process. The system can records all the information of the whole process. Log files that help to complete the traceability functionality can be easily exported to the SD card.

    User ID LIMS Barcode ID Report
    User ID LIMS Barcode ID Report
    10 user ID with individual code
    1 admin ID for lab keeper
    Sample ID scanning
    Cartridge ID scanning
    Elution tube ID scanning
    Automatic video recording
    Traceability report with user ID

    MagPurix 12 N.E.O.

    Product Name Description
    MagPurix 12 N.E.O. 1-12 simultaneously biological samples

    Key Features of MagPurix 12 N.E.O.

    • Smart and intuitive user interface allowing fast operation
    • Optimized protocols and optimized reaction chamber resulting in short processing time and high efficiency
    • New technology for Heating and Magnet Module improving instrument reliability
    • Advanced functionality accessible with a computer connected to the instrument, allowing access to any desired run, log, protocol settings, and more

    Smart Operation of MagPurix 12 N.E.O.

    User ID Barcode ID Load Automatic Process
    User ID Barcode ID Load Automatic Process
    Scan User ID barcode for quick log in Scan QR Code for protocol and sample info Automatic open/close tray for easy sample load One-click start and fully automated from start to finish

    Compatible MagPurix DNA/RNA Extraction Kits

    Type Product Name Application Sample Volume
    RNA MagPurix® Coronavirus RNA Extraction Kit For extracting viral RNA viral RNA from serum, plasma, saliva, sputum, swabs, cell-free body fluids and cerebrospinal fluid (CSF). (For MagPurix EVO only) 100 – 200 µl
    MagPurix® Total RNA Extraction Kit For extracting total RNA from mammalian whole blood, human and animal tissues, cultured cells, plant tissue and yeast.  
    MagPurix® Viral RNA Extraction Kit For extracting viral RNA from cell-free samples, such as serum, plasma, CSF, urine and other cell-free body fluids.  
    cfDNA MagPurix® CFC DNA Extraction Kit For extracting cfDNA from cell-free samples, such as plasma, or from a pool of cell-free body fluids. 1,000 – 2,000 µl
    MagPurix® cfDNA Extraction Kit Plus For extracting cfDNA from cell-free samples, such as plasma, or from a pool of cell-free body fluids. (For MagPurix EVO only) 1,000 – 2,000 µl
    MagPurix® cfDNA Extraction Kit LV For extracting cfDNA from cell-free samples, such as plasma, or from a pool of cell-free body fluids. (For MagPurix EVO only) 2,000 – 5,000 µl
    MagPurix® Plasma cfDNA Extraction Kit For extracting cfDNA from plasma samples. (For MagPurix EVO only)  
    MagPurix® Urine cfDNA Extraction Kit For extracting cfDNA from urine samples. (For MagPurix EVO only)  
    DNA MagPurix® Plant DNA Extraction Kit For extracting gDNA from a variety of plant samples and yeast.  
    MagPurix® Forensic DNA Extraction Kit For extracting DNA from human whole blood, dried blood, hair roots, tissues, saliva and other forensic samples.  
    MagPurix® FFPE DNA Extraction Kit For extracting DNA and RNA from formalin-fixed, paraffin- embedded (FFPE) tissue samples and needle biopsies.  
    MagPurix® HPV DNA Extraction Kit for Swab Samples For extracting HPV DNA from cervical swab samples, collected in transport medium. up to 400 µl
    MagPurix® Bacterial DNA Extraction Kit For extracting bacterial nucleic acid from human biological specimens, inactivated pathogenic microorganisms, bacterial colonies from culture, and environment material.  
    MagPurix® Cultured Cell DNA Extraction Kit For extracting DNA from cultured cells and purified buffy coat (red blood cell-free). up to 400 μl
    MagPurix® Tissue DNA Extraction Kit For extracting DNA and RNA from human and animal tissue, dried swabs and dried blood spots.  
    MagPurix® Blood DNA Extraction Kit 1200 For extracting genomic DNA from mammalian whole blood, suspension of mammalian blood cells, and buffy coat. up to 1,000 μl
    MagPurix® Blood DNA Extraction Kit 200 For extracting genomic DNA from mammalian whole blood, suspension of mammalian blood cells, and buffy coat. up to 400 μl
    Nucleic Acid MagPurix® Viral Nucleic Acid Extraction Kit For extracting viral nucleic acid from serum, plasma, cell-free body fluids, and swab samples in transport medium. up to 400 μl
    MagPurix® Viral Nucleic Acid Extraction Kit LV For extracting viral nucleic acid from serum, plasma, cell-free body fluids, and swab samples in transport medium. up to 2,000 µl
    MagPurix® Viral/Pathogen Nucleic Acids Extraction Kit B For extracting viral and bacterial DNA/RNA from swab samples in liquid transport media, inactivated pathogenic microorganism and pathogen cultures.  
    MagPurix® Viral/Pathogen Nucleic Acids Extraction Kit A For extracting viral and bacterial DNA/RNA from cell-free samples, such as serum, plasma, CSF, urine and other cell- free body fluids.  

    Outstanding Performance of MagPurix Automated Systems

    Stability

    DNA was extracted from whole blood containing different anticoagulants or under different storage conditions using the MagPurix Blood DNA Extraction Kit 200. The results of β-globin DNA (Fig.A) and spiked parvovirus B-19 DNA (Fig.A&B) detection by real-time qPCR showed that the samples were not significantly affected by different anticoagulants and storage conditions.

    β-globin DNA detected by Real-time qPCRFigure A. β-globin DNA detected by Real-time qPCR

    β-globin DNA and parvovirus B-19 DNA detected by Real-time qPCRFigure B. β-globin DNA and parvovirus B-19 DNA detected by Real-time qPCR

    Reproducibility

    DNA was isolated from 20 whole blood samples using the MagPurix Blood DNA Extraction kit. The results of β-globin gene detection by real-time qPCR showed that the MagPurix 12 EVO nucleic acid purification system was extremely stable and reproducible.

    Real-time qPCR detection of β-globin gene extracted by MagPurix 12 EVOFigure C. Real-time qPCR detection of β-globin gene extracted by MagPurix 12 EVO

    Sensitivity and Linearity

    Serial diluted human parvovirus B19 (range of 250-2.5 million IU/ml) were added to whole blood. 200ml sample was extracted and eluted in 100ml. The 10ml eluate was detected by real-time PCR and the results showed that 5 IU spiked sample (approximately 1 IU in the PCR reaction) was detected, thus demonstrating the sensitivity and linearity of the MagPurix system for isolating nucleic acids.

    Real-time PCR detection of human parvovirus B19 DNAFigure D. Real-time PCR detection of human parvovirus B19 DNA

    200µl of serum sample containing serial dilutions of hepatitis B virus (range 300,000 to 30 IU/ml) was extracted and eluted in 100µl. The sensitivity and linearity of the separation method were demonstrated by the detection of 30µl of the eluate using real-time PCR, which detected less than 6 IU spiked (approximately 1 IU in the PCR reaction) sample.

    Real-time PCR detection of hepatitis B virus (HBV) DNAFigure E. Real-time PCR detection of hepatitis B virus (HBV) DNA

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