The study of DNA and RNA is central to basic research, clinical diagnostics, forensics, and biotechnology. Automated and specialized instruments have been developed to perform nucleic acid extraction, purification, and analysis. These automated systems provide significant advantages over traditional manual methods in terms of speed, accuracy, reproducibility, and sensitivity.
Nucleic acid extraction is the first step in isolating DNA and RNA from biological samples and involves lysing cells or viruses, releasing nucleic acids, and removing proteins and other contaminants. Automated nucleic acid extraction instruments use chemical buffers and digestive enzymes along with heat treatment, beading, or centrifugation to extract nucleic acid samples. Through integrating these steps with precision fluidics, automated extraction of nucleic acids yields higher than manual techniques, while reducing time consumption and contamination risks. Automated systems can be adapted to a wide range of sample types, and parallel processing enables high throughput extraction.
The magnetic bead-based automatic nucleic acid extraction instrument utilizes a specific binding agent on the surface of magnetic beads with magnetic properties to bind to nucleic acids and then separates the beads from the bound nucleic acids by a magnetic field.
Automatic nucleic acid extraction instrument based on the silicone membrane method or glass fiber membrane method uses the surface properties of the membrane to adsorb nucleic acids onto the membrane, and then the extracted nucleic acids are eluted from the membrane through washing, centrifugation, and other steps.
Automatic nucleic acid extraction instruments based on microfluidic chips utilize structures such as microchannels and microvalves in the microfluidic chip to separate and purify nucleic acids through precise control and distribution of liquid.
After extraction, further purification is needed to remove proteins, salts, and other impurities that may interfere with analysis. Automated nucleic acid purification instruments employ solid phase extraction using membranes, magnetic beads, or silica columns to selectively bind and wash nucleic acids. Optimized buffers and washes ensure the purification of high-quality DNA and RNA. Purified DNA and RNA can then be subjected to various analyses, such as quantification, sequencing, genotyping, and other nucleic acid analyses.
The high-throughput capabilities of automated instruments facilitate biomolecular research, disease research, and drug and diagnostic development.
The wave of automation has led to significant advances in every aspect of nucleic acid extraction, purification, and analysis. Amerigo Scientific offers automated nucleic acid extraction instruments that increase speed, precision, and sensitivity while minimizing errors and contamination.
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