Name: PD0325901
Price: 188.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    PD0325901 is a specific inhibitor of mitogen-activated protein kinase MEK. PD0325901 is a small molecular with the formula of C16H14F3IN2O4 and Molecular Weight of 482. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, and MEK/ERK regulates cell proliferation, survival, and differentiation in response to extracellular signals. PD0325901 effectively reduces P-ERK levels and cell growth in vitro, and inhibits tumor growth in mouse model in vivo
    
    1. Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901. J Leyton, G Smith, M Lees, M Peruma. Molecular cancer Therapeutics. 2008
    2. Targeting mitogen‐activated protein kinase kinase with the inhibitor PD0325901 decreases hepatocellular carcinoma growth in vitro and in mouse model. M Hennig, MT Yip‐Schneider, S Wentz, H Wu. Hepatology. 2010
- Properties
  - Alternative Name
    
    PD0325901,PD-0325901,PD 0325901,PD325901,PD 325901,PD-325901; N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
    
    CAS Number
    
    391210-10-9
    
    Molecular Formula
    
    C16H14F3IN2O4
    
    Molecular Weight
    
    482.19
    
    Appearance
    
    A solid
    
    Purity
    
    99.64%
    
    Solubility
    
    ≥24.1 mg/mL in DMSO; insoluble in H2O; ≥55.4 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Shengyun Ma, Shefali A. Patel, et al. " RORγt phosphorylation protects against T cell-mediated inflammation." Cell Rep. 2022 Mar 15;38(11):110520. PMID: 35294872
    2. Mengfei Zhang, Na Li, et al. "Eif2s3y Promotes the Proliferation of Spermatogonial Stem Cells by Activating ERK Signaling." Stem Cells Int. 2021 Jan 29;2021:6668658. PMID: 33603791
    3. White SM, Avantaggiati ML, et al. "YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells." Dev Cell. 2019 May 6;49(3):425-443.e9. PMID: 31063758
    4. Sima J, Chakraborty A, et al. "Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication." Cell. 2019 Feb 7;176(4):816-830.e18. PMID: 30595451
    5. Wang Y, Li Y, et al. "The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation." FASEB J. 2018 Sep 25:fj201800343R. PMID: 30252535
    6. Kopanitsa MV, Gou G, et al. "Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1(+/-) mice." Pharmacol Rep. 2018 Jun 22;70(4):777-783. PMID: 29940508
    7. Potonjak I, Gobin I, et al. "Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: Involvement of MEK-ERK activation." Phytother Res. 2018 Feb 8. PMID: 29417642
    8. Sieber J, Wieder N, et al. "GDC-0879, a BRAF(V600E) Inhibitor, Protects Kidney Podocytes from Death." Cell Chem Biol. 2017 Dec 6. PMID: 29249695

PD0325901

PD0325901

Background

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