Name: StemRegenin 1 (SR1)
Price: 196.00 USD

- Overview
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    Background
    
    StemRegenin 1 (SR1), a purine derivative, is a potent small molecule inhibitor of aryl hydrocarbon receptor (AhR) that potently antagonizes AhR with a value of 50% inhibition concentration IC50 of 127 nM in CD34+ cells. SR1 has been found to promote the ex vivo expansion of CD34+ cells. Recent study results have suggested that culture of hematopoietic stem cells (HSC) with SR1 increases cells expressing CD34 by fifty-fold and increases cells retaining the ability to engraft immunodeficient mice by 17-fold. SR1 has also been found to induce the ex vivo differentiation of pDCs, BDCA1+ and BDCA3+ mDCs as well as the generation of high numbers of all these DC subsets.
- Properties
  - Categories
    
    AhR antagonist
    
    Alternative Name
    
    4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol
    
    CAS Number
    
    1227633-49-9
    
    Molecular Formula
    
    C24H23N5OS
    
    Molecular Weight
    
    429.54
    
    Appearance
    
    A solid
    
    Purity
    
    97.00%
    
    Solubility
    
    ≥21.5 mg/mL in DMSO; insoluble in H2O; ≥3.41 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C)N1C=NC2=C1N=C(N=C2NCCC3=CC=C(C=C3)O)C4=CSC5=CC=CC=C54
    
    * For Research Use Only