• Amerigo Scientific Instrument

    Proteolysis targeting chimeras (PROTACs) are small molecules formulated to discerningly degrade target proteins within cells. They encompass two fundamental constituents: a ligand that recognizes the desired target protein and a ligand that binds to an E3 ubiquitin ligase. The E3 ligase actively recruits the protein of interest (POI) to the intracellular degradation apparatus, thereby instigating the disintegration of target protein through the proteasome. PROTACs have exhibited promising efficacy in the selective degradation of diverse disease-associated proteins, including oncogenic proteins and resistant variants. PROTACs hold great potential for therapeutic applications in the treatment of myriad ailments, yet further scientific exploration and progression are requisite to surmount hurdles such as maximizing molecular design and refining selectivity.

    Amerigo Scientific offers PROTAC linkers, PROTAC target protein ligands, E3 ligase ligands, E3 ligase ligand-linker conjugates, target protein ligand-linker conjugates, and others. PROTACs-induced targeted protein degradation is an emerging therapeutic strategy with the potential to tackle disease-causing proteins.

    Products (94)
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    V3577
    • Size:
    • Catalog Number: PTC1441538INV
    V3487
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    • Catalog Number: PTC1441537INV
    V37538
    • Size:
    • Catalog Number: PTC1441536INV
    V37563
    • Size:
    • Catalog Number: PTC1441535INV
    V37546
    • Size:
    • Catalog Number: PTC1441534INV
    V37562
    • Size:
    • Catalog Number: PTC1441533INV
    V37561
    • Size:
    • Catalog Number: PTC1441532INV
    V37549
    • Size:
    • Catalog Number: PTC1441531INV
    V37539
    • Size:
    • Catalog Number: PTC1441530INV
    V37540
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    • Catalog Number: PTC1441529INV
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