Histology is the microscopic study of cells and tissues through staining sectioning and examining them under a microscope to understand their organization and characteristics. Histology laboratory equipment includes a variety of instruments and consumables, and most commonly used of which are tissue processors, embedding centers, cryostats, sectioning equipment, and stainers used to prepare and analyze tissue samples. Many instruments and supplies are becoming more advanced to meet the higher requirements of histological research projects.
Microtomes are cutting instruments that allow precise, controlled sectioning of paraffin-embedded tissue blocks. These instruments can be manual or motorized, and come with adjustable cutting thicknesses and feeders for consistent and reproducible sections. Researchers and pathologists can use these devices to obtain thin sections of tissue samples for a variety of histologic and pathologic analyses. Cryostats are specialized equipment that rapidly freezes tissues, allowing them to be sectioned without embedding them in paraffin. The instruments are used to section frozen tissue samples for immediate analysis and study of fresh or frozen tissue. The temperature-controlled cutting platform of cryostats maintains the tissue at a low temperature, ensuring the preservation of tissue morphology during sectioning.
Tissue processors are automated devices used to prepare tissue samples for histological analysis. These devices help in the fixation, dehydration, removal, and paraffin embedding of tissues. The use of tissue processors can ensure consistent and standardized processing of tissue samples, optimal preservation of cellular structures, and accurate interpretation under the microscope.
Embedding centers usually consist of a heated wax bath that maintains the wax at the proper temperature for tissue infiltration and a cold plate that is used to quickly solidify the embedded tissue sample. The embedding center provides a controlled environment for tissue embedding procedures, ensuring proper tissue orientation, avoiding thermal damage, and creating the ideal wax block shape.
Stainers are used to apply specific stains to tissue sections to improve the visibility of the tissue sections and to highlight specific tissue components or pathologic features to help identify cellular components and structures. These instruments automate the staining process, improving reproducibility and reducing hands-on time.
In addition to instruments, thin and sharp blades are available in different profiles and cutting-edge angles to accommodate different cutting requirements and tissue types, ensuring precise and clean sectioning of tissue samples. Embedding cassettes and other biopsy supplies are commonly used consumables for holding tissue samples during the embedding process, allowing for optimal wax infiltration and solvent exchange during tissue processing.
Histology laboratory equipment can be applied to study tissue structure, cell morphology, and molecular changes for cancer research, tissue engineering, regenerative medicine, drug research and pharmacology, developmental biology research, etc. Structure, and tissue arrangement of cells and tissues, function under physiological and pathological conditions, and processes of compound absorption, distribution, metabolism, and excretion are well understood through this research method. Amerigo Scientific offers relevant instruments and supplies to prepare examine and analyze tissue samples to help gain insight into the structure and characteristics of physiological and pathological tissues within living organisms.
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