Stauprimide

- Overview
  - Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as potential antitumor agents. Stauprimide increases the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signalling cues.
    
    Stauprimide is soluble in ethanol, methanol, DMF and DMSO.
    
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    Background
    
    Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.
- Properties
  - CAS Number
    
    154589-96-5
    
    Molecular Formula
    
    C35H28N4O5
    
    Molecular Weight
    
    584.6
    
    Appearance
    
    Yellow orange solid
    
    Storage
    
    -20°C
    
    * For research use only