Mononucleotides and Nucleosides

Nucleosides are structural subunits of nucleic acids, consisting of bases and five-carbon sugars. In all organisms, nucleosides are responsible for encoding, transmitting, and expressing genetic information. Nucleotides are composed of a nucleoside and at least one phosphate group. The nucleotides are either ribonucleotides or deoxyribonucleotides, and they are found either as mono-, di-, or triphosphates. The triphosphates are substrates for RNA and DNA polymerases. The mono- and diphosphates are intermediates in the biosynthetic reactions and also arise from hydrolytic and/or phosphorolytic breakdown of nucleic acids or other metabolic activities either inside the cells or outside by decay of biological material.

Amerigo Scientific offers a variety of triphosphates and base-protected or unprotected nucleosides for the synthesis of nucleic acids, including standard nucleosides, modified nucleosides, partially protected nucleosides, 4,4'-dimethoxytrityl (DMT) protected deoxy nucleosides, DMT protected ribonucleosides, and more.