• Amerigo Scientific Instrument
  • Allevi

    3D Bioprinting

    Advances in 3D printing technology, cell biology and materials science have made 3D bioprinting as a form of tissue engineering possible. In 3D bioprinting, layer-by-layer precise positioning of biomaterials or bioinks and cells, with spatial control of the placement of functional components, is used to fabricate biological constructs that maximally imitate natural characteristics.

    3D Bioprinting

    3D bioprinting technology can be used in regenerative medicine to address the need for tissues and organs suitable for transplantation and is also available for in vitro/in vivo modeling, production of drug delivery systems, and drug screening in the pharmaceutical field.

    >> 3D Bioprinters

    3D bioprinters can be commonly classified into four groups based on their working principles: inkjet-based, extrusion-based, laser-assisted, stereolithography bioprinters. Extrusion-based bioprinting technology is widely used due to its simplicity, diversity and, predictability.

    Allevi bioprinters are extrusion-based bioprinters that can deal with high cell density, viscosities, and dynamical crosslinking mechanisms. Allevi bioprinters deposit bioinks in a layer-by-layer fashion through the forces exerted by pneumatic pressure making it very easy to achieve clean starts and stops in printing. Moreover, they can produce cell-laden bioinks in the form of continuous extruded strands which can engineer a large-scale biomimetic structure by use of their speedy printing velocity.

    Allevi 1 Small Footprint, Big Impact

    Allevi 1
    Small Footprint, Big Impact

    Allevi 2 The Original Desktop 3D Bioprinter

    Allevi 2
    The Original Desktop 3D Bioprinter

    Allevi 3 The Bioprinter for Every Application

    Allevi 3
    The Bioprinter for Every Application

    >> Biomaterials & Bioinks

    Bioink is a solution of a biomaterial or a mixture of several biomaterials in the hydrogel form, usually encapsulating living cells, and/or bioactive molecules. Bioinks are cross-linked or stabilized during or immediately after the bioprinting to create the final shapes of the intended tissue constructs.

    Ideal bioinks should possess the desired physicochemical properties, such as cross-linking capability, mechanical, rheological, chemical, and biological characteristics. High standards of bioinks from Allevi meet your high standards for research.

    • The bioinks are largely human and animal-derived and do not contain viscosity agents that can negatively affect tissue viability and function.
    • The bioinks have been thoroughly tested by academia and the tissue engineering industry, and have been proven to yield the best biological results.

    With multimaterial bioprinting technology, Allevi bioprinters are compatible with a myriad of biomaterials (synthetic polymers, cellular aggregates, microcarriers, etc.) and print several materials in one session. The selection of appropriate bioinks depends on the bioprinter to be used, as well as the specific application and the type of cells.

    Cells and Bioinks for Bioprinting Tissues:

      • Liver
        • Cells Bioinks Additives
          Human Hepatocytes Collagen Lifeink® 200 Allevi Liver DECM
          Methacrylated Hyaluronic Acid LAP Photoinitiator
          Methacrylated Collagen Ruthenium
          PureCol® Type 1 Bovine Collagen
          Gelatin Methacrylate
          Gelatin Methacrylate Solution - Sterile
          Thiolated Hyaluronan
      • Heart
        • Cells Bioinks Additives
          Human Umbilical Vein Endothelial Cells Collagen Lifeink® 200 Tropoelastin
          Collagen Lifeink® 240 Fibronectin
          Methacrylated Hyaluronic Acid RGD Peptide
          Methacrylated Collagen LAP Photoinitiator
          PureCol® Type 1 Bovine Collagen Ruthenium
          Gelatin Methacrylate
          Gelatin Methacrylate Solution - Sterile
          Thiolated Hyaluronan
          Sodium Alginate
      • Bone
      • Cartilage
      • Kidney
        • Cells Bioinks Additives
          Collagen Lifeink® 200 Bovine Collagen Type II
          Methacrylated Hyaluronic Acid RGD Peptide
          Methacrylated Collagen LAP Photoinitiator
          PureCol® Type 1 Bovine Collagen Ruthenium
          Gelatin Methacrylate
          Gelatin Methacrylate Solution - Sterile
          Thiolated Hyaluronan
          Sodium Alginate
      • Nervous System
      • Skin
        • Cells Bioinks Additives
          Human Dermal Fibroblasts, Neonatal ( NHDF-Neo) Collagen Lifeink® 200 Bovine Collagen Type II
          Human Dermal Fibroblasts, Adult (NHDF-Ad) Methacrylated Hyaluronic Acid Human Collagen, Type III
          Methacrylated Collagen Human Collagen, Type IV
          PureCol® Type 1 Bovine Collagen Bovine Collagen Type V
          Gelatin Methacrylate Tropoelastin
          Gelatin Methacrylate Solution - Sterile Fibronectin
          Thiolated Hyaluronan LAP Photoinitiator
          Ruthenium
      • Vascularization
        • Cells Bioinks Additives
          Human Umbilical Vein Endothelial Cells Collagen Lifeink® 200 Human Collagen, Type III
          Methacrylated Hyaluronic Acid Bovine Collagen Type V
          Methacrylated Collagen Tropoelastin
          PureCol® Type 1 Bovine Collagen Fibronectin
          Gelatin Methacrylate Vitronectin
          Gelatin Methacrylate Solution - Sterile LAP Photoinitiator
          Pluronic Ruthenium
          Carbohydrate Glass
          Gelatin
      • Lung
        • Cells Bioinks Additives
          Collagen Lifeink® 200 Human Collagen, Type III
          Methacrylated Hyaluronic Acid Bovine Collagen Type V
          Methacrylated Collagen Tropoelastin
          PureCol® Type 1 Bovine Collagen LAP Photoinitiator
          Gelatin Methacrylate Ruthenium
          Gelatin Methacrylate Solution - Sterile
          Thiolated Hyaluronan
      • Brain
        • Cells Bioinks Additives
          Methacrylated Hyaluronic Acid RGD Peptide
          Methacrylated Collagen LAP Photoinitiator
          PureCol® Type 1 Bovine Collagen Ruthenium
          Silk, Fibroin
          Sodium Alginate
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