Allevi

3D Bioprinting

Advances in 3D printing technology, cell biology and materials science have made 3D bioprinting as a form of tissue engineering possible. In 3D bioprinting, layer-by-layer precise positioning of biomaterials or bioinks and cells, with spatial control of the placement of functional components, is used to fabricate biological constructs that maximally imitate natural characteristics.

3D Bioprinting

3D bioprinting technology can be used in regenerative medicine to address the need for tissues and organs suitable for transplantation and is also available for in vitro/in vivo modeling, production of drug delivery systems, and drug screening in the pharmaceutical field.

>> 3D Bioprinters

3D bioprinters can be commonly classified into four groups based on their working principles: inkjet-based, extrusion-based, laser-assisted, stereolithography bioprinters. Extrusion-based bioprinting technology is widely used due to its simplicity, diversity and, predictability.

Allevi bioprinters are extrusion-based bioprinters that can deal with high cell density, viscosities, and dynamical crosslinking mechanisms. Allevi bioprinters deposit bioinks in a layer-by-layer fashion through the forces exerted by pneumatic pressure making it very easy to achieve clean starts and stops in printing. Moreover, they can produce cell-laden bioinks in the form of continuous extruded strands which can engineer a large-scale biomimetic structure by use of their speedy printing velocity.

5 top technologies of the Allevi bioprinters are sacrificial bioprinting, direct casting, freeform reversible embedding of suspended hydrogels (FRESH), multi-material bioprinting, and coaxial kit.

Please click here to view the comparison between parameters of the three bioprinters.

>> Biomaterials & Bioinks

Bioink is a solution of a biomaterial or a mixture of several biomaterials in the hydrogel form, usually encapsulating living cells, and/or bioactive molecules. Bioinks are cross-linked or stabilized during or immediately after the bioprinting to create the final shapes of the intended tissue constructs.

Ideal bioinks should possess the desired physicochemical properties, such as cross-linking capability, mechanical, rheological, chemical, and biological characteristics. High standards of bioinks from Allevi meet your high standards for research.

  • The bioinks are largely human and animal-derived and do not contain viscosity agents that can negatively affect tissue viability and function.
  • The bioinks have been thoroughly tested by academia and the tissue engineering industry, and have been proven to yield the best biological results.

With multimaterial bioprinting technology, Allevi bioprinters are compatible with a myriad of biomaterials (synthetic polymers, cellular aggregates, microcarriers, etc.) and print several materials in one session. The selection of appropriate bioinks depends on the bioprinter to be used, as well as the specific application and the type of cells.

Cells and Bioinks for Bioprinting Tissues:

    • Liver
      • Cells Bioinks Additives
        Human Hepatocytes Collagen Lifeink® 200 Allevi Liver DECM
        Methacrylated Hyaluronic Acid LAP Photoinitiator
        Methacrylated Collagen Ruthenium
        PureCol® Type 1 Bovine Collagen
        Gelatin Methacrylate
        Gelatin Methacrylate Solution - Sterile
        Thiolated Hyaluronan
    • Heart
      • Cells Bioinks Additives
        Human Umbilical Vein Endothelial Cells Collagen Lifeink® 200 Tropoelastin
        Collagen Lifeink® 240 Fibronectin
        Methacrylated Hyaluronic Acid RGD Peptide
        Methacrylated Collagen LAP Photoinitiator
        PureCol® Type 1 Bovine Collagen Ruthenium
        Gelatin Methacrylate
        Gelatin Methacrylate Solution - Sterile
        Thiolated Hyaluronan
        Sodium Alginate
    • Bone
    • Cartilage
    • Kidney
      • Cells Bioinks Additives
        Collagen Lifeink® 200 Bovine Collagen Type II
        Methacrylated Hyaluronic Acid RGD Peptide
        Methacrylated Collagen LAP Photoinitiator
        PureCol® Type 1 Bovine Collagen Ruthenium
        Gelatin Methacrylate
        Gelatin Methacrylate Solution - Sterile
        Thiolated Hyaluronan
        Sodium Alginate
    • Nervous System
    • Skin
      • Cells Bioinks Additives
        Human Dermal Fibroblasts, Neonatal ( NHDF-Neo) Collagen Lifeink® 200 Bovine Collagen Type II
        Human Dermal Fibroblasts, Adult (NHDF-Ad) Methacrylated Hyaluronic Acid Human Collagen, Type III
        Methacrylated Collagen Human Collagen, Type IV
        PureCol® Type 1 Bovine Collagen Bovine Collagen Type V
        Gelatin Methacrylate Tropoelastin
        Gelatin Methacrylate Solution - Sterile Fibronectin
        Thiolated Hyaluronan LAP Photoinitiator
        Ruthenium
    • Vascularization
      • Cells Bioinks Additives
        Human Umbilical Vein Endothelial Cells Collagen Lifeink® 200 Human Collagen, Type III
        Methacrylated Hyaluronic Acid Bovine Collagen Type V
        Methacrylated Collagen Tropoelastin
        PureCol® Type 1 Bovine Collagen Fibronectin
        Gelatin Methacrylate Vitronectin
        Gelatin Methacrylate Solution - Sterile LAP Photoinitiator
        Pluronic Ruthenium
        Carbohydrate Glass
        Gelatin
    • Lung
      • Cells Bioinks Additives
        Collagen Lifeink® 200 Human Collagen, Type III
        Methacrylated Hyaluronic Acid Bovine Collagen Type V
        Methacrylated Collagen Tropoelastin
        PureCol® Type 1 Bovine Collagen LAP Photoinitiator
        Gelatin Methacrylate Ruthenium
        Gelatin Methacrylate Solution - Sterile
        Thiolated Hyaluronan
    • Brain
      • Cells Bioinks Additives
        Methacrylated Hyaluronic Acid RGD Peptide
        Methacrylated Collagen LAP Photoinitiator
        PureCol® Type 1 Bovine Collagen Ruthenium
        Silk, Fibroin
        Sodium Alginate

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