Stem Cell related Antibody Products

Stem Cell related Antibody Products


Background

Amerigo Scientific provides a comprehensive range of antibody products for researchers and scientists in multiple research fields of stem cells. Our stem cell antibody products help to study stem cell differentiation, proliferation, and signaling, supporting advancements in regenerative medicine, disease modeling, and therapeutic development with accurate and reproducible results.

Stem cells are undifferentiated cells with the potential to renew themselves and differentiate into particular cell types. They possess unique characteristics including pluripotency (able to give rise to many cell types), multipotency (capable of differentiating into closely related cell types), and the ability to renew themselves through cell division. Stem cells are crucial in the formation, regeneration and upkeep of adult tissues. Their ability to replace damaged cells offers promise for treating multiple kinds of illnesses and injuries.

Types of Stem Cells

Embryonic Stem Cells (ESCs) Adult Stem Cells Induced Pluripotent Stem Cells
Source Derived from the inner cell mass of blastocysts, an early-stage pre-implantation embryo. Located in specific tissues like skin, brain, liver, and bone marrow. Created by reprogramming differentiated adult cells (e.g., skin cells) back into a pluripotent state through genetic manipulation.
Property Pluripotent, which means they can differentiate into almost any sort of cell in the body. Typically multipotent, able to differentiate into a restricted spectrum of cell types fitting to the tissue or organ they inhabit. Pluripotent, similar to ESCs, capable of differentiating into any cell type.
Function Crucial for early development and hold vast potential for regenerative medicine due to their capacity to create any tissue type. In charge of the maintenance, repair, and regeneration of their resident tissues, replacing damaged or worn-out cells. Providing an alternative to ESCs in research and therapy, offering patient-specific cells for disease modeling, drug testing, and potential regenerative treatments without the ethical concerns associated with using embryos.

Applications of Stem Cells

Stem cells have revolutionized biomedical research and therapeutic possibilities with their diverse applications. In cell-based therapies, stem cells have the potential to treat diseases spanning from neurodegenerative disorders to heart failure, leveraging their ability to regenerate damaged tissues. They also enhance our understanding of disease development by serving as models for studying genetic disorders and complex diseases in controlled laboratory environments. Moreover, stem cells play a crucial role in screening new drugs, providing platforms to test efficacy and safety before advancing to clinical trials, thereby accelerating the development of novel therapeutic interventions.

Fig.1 The research applications of stem cells.Fig.1 Stem cells in disease modeling, toxicity studies, drug discovery, and cell therapy for cardiovascular diseases.1

Amerigo Scientific supports disease model research, drug development screening, and cell therapy research based on different stem cells. Some stem cell types are shown below. In addition, widely used and highly stable antibody-based research methods are provided to help your stem cell research.

  • Cancer stem cells (CSCs) are a subgroup of cancer cells that can self-renew and differentiate into many cell types observed in tumors. They are involved in tumor initiation, development, metastasis, and recurrence, making them a significant focus for cancer therapies.
  • ESCs are pluripotent cells generated from the initial phase of embryos. They may differentiate into every cell type in the body and have indefinite self-renewal capabilities.
  • Germline stem cells are responsible for producing gametes (sperm and eggs) in the reproductive organs. They play a vital role in reproduction and heredity, ensuring the transmission of genetic information to the next generation.
  • Hematopoietic progenitors are stem cells found in the bone marrow that produce any blood cell types. Hematopoietic progenitors are crucial for maintaining blood homeostasis and are widely used in bone marrow transplants.
  • Mesenchymal stem cells, a kind of multipotent cells, are present in multiple organs including adipose tissue and bone marrow. They can develop into fat, cartilage, muscle, and bone cells, and possess anti-inflammatory and immunomodulatory capabilities.
  • Neural stem cells (NSCs) are located in the brain and spinal cord, and can differentiate into neurons, astrocytes, and oligodendrocytes, playing a vital role in brain development, maintenance, and repair.
  • Stem cell markers are specific proteins or antigens found on the surface of stem cells, used to identify and isolate different stem cell populations. Common markers include CD34 for hematopoietic stem cells, Oct4 for embryonic stem cells, and Nestin for neural stem cells.

Contact us to learn more about stem cell-related products and services.

Reference

  1. Correia, Cátia D., et al. "Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?." Cells 12.13 (2023): 1727. Distributed under Open Access license CC BY 4.0, without modification.

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