IL2RB

Full Name: Interleukin 2 Receptor Subunit Beta

BACKGROUND: The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system.

Synonyms: IL2RB; interleukin 2 receptor, beta; CD122; IL15RB; P70-75; interleukin-2 receptor subunit beta; p75; IL-2RB; CD122 antigen; IL-2R subunit beta