Full Name: Poliovirus receptor
BACKGROUND: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication.
Synonyms: PVS; HVED; CD155; NECL5; TAGE4; Necl-5
Research Areas: Immunology
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