Full Name: Angiopoietin 2
BACKGROUND: The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms: ANGPT2; angiopoietin 2; ANG2; AGPT2; ANG-2; Tie2-ligand
Research Areas: Cardiovascular Biology
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