MFGE8

Full Name: Milk Fat Globule-EGF Factor 8 Protein

BACKGROUND: This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants.

Synonyms: Milk Fat Globule-EGF Factor 8 Protein; Breast Epithelial Antigen BA46; Sperm Associated Antigen 10; Sperm Surface Protein HP47; Lactadherin; MFG-E8; HMFG; MFGM; SED1; O-Acetyl Disialoganglioside Synthase