Antibodies have a variety of biological functions owing to their ability to bind their target antigen with high specificity. Some of the main functions of antibodies include the neutralization of infectious agents, activation of the complement system, and opsonization which enhances phagocytosis of antigens. The binding of antibodies to their corresponding Fc receptors initiates several effector functions, e.g. complement activation (CDC), antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC).in various techniques such as immunofluorescence, immunohistochemistry, flow cytometry, western blotting, ELISA, etc.
Fig.1 The relevant effector functions of approved therapeutic antibodies.1
Functional grade antibodies are antibodies that have undergone special purification procedures to remove any contaminants such as endotoxins or other proteins that may interfere with the desired in-vivo or in-vitro experiment. They are often used for functional assays, in vivo studies, or cell culture applications since they are engineered to work effectively without causing harmful side effects such as non-specific binding, cross-reactivity, or intense immune responses. Functional antibodies can be used in the following applications:
At Amerigo Scientific, we offer a wide range of functional-grade antibodies that have been specially processed to remove additional components such as endotoxin and preservatives. These antibodies undergo rigorous testing to confirm their activity and purity.
As an alternative of original therapeutic product, the research biosimilar antibodies aims to offer cost-effective solutions for drug research studies and assay development.
In vivo antibodies are manufactured and tested to ensure they will not have harmful effects when used in living organisms. They can be used in immunotherapy, oncology, infectious disease, autoimmune disorder studies, and etc.
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