Full Name: Transmembrane And Immunoglobulin Domain Containing 2
BACKGROUND: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Synonyms: B7-H7CR; B7-H7 counter-receptor; CD28H
Research Areas: Cell Biology
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