EPHA3

Full Name: EPH Receptor A3

BACKGROUND: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.

Synonyms: EPH Receptor A3; Tyrosine-Protein Kinase Receptor ETK1; Eph-Like Tyrosine Kinase 1; EPH-Like Kinase 4; EC 2.7.10.1; TYRO4; HEK4; ETK1; ETK; EK4