NTRK1

Full Name: Neurotrophic Receptor Tyrosine Kinase 1

BACKGROUND: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Synonyms: Neurotrophic Receptor Tyrosine Kinase 1; Neurotrophic Tyrosine Kinase, Receptor, Type 1; High Affinity Nerve Growth Factor Receptor; TRK1-Transforming Tyrosine Kinase Protein; Tropomyosin-Related Kinase A; Tyrosine Kinase Receptor A; EC 2.7.10.1; P140-TrkA; Gp140trk; Trk-A