XCR1

Full Name: X-C Motif Chemokine Receptor 1

BACKGROUND: The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains. The encoded protein transduces a signal by increasing the intracellular calcium ion level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Some studies have implicated a cluster of genes at 3p21.31, including this gene, as associated with COVID-19 risk. The encoded protein may also play a role in cell proliferation and migration in several types of cancer.

Synonyms: Gpr5; mXcr1; Ccxcr1; chemokine XC receptor 1; C motif-1/lymphotactin receptor; SCM1 receptor; XC chemokine receptor 1; chemokine (C motif) XC receptor 1; lymphotactin receptor