Adaptor Protein related Antibody Products

Adaptor proteins, typically characterized by having multiple protein-binding domains, coordinate signal transduction cascades to mediate various cellular functions including motility, activation, proliferation, and differentiation. By binding related proteins or domains, adaptor proteins form larger complexes that propagate and amplify cellular signals. Amerigo Scientific provides antibodies targeting adaptor proteins, serving as essential tools for advancing neuroscience research. These antibodies aid our esteemed clients in studying adaptor proteins and can be utilized in biomarker assays for early diagnosis.

Overview of Adaptor Proteins

Adaptor proteins are essential for cell proliferation and survival by regulating signal transduction. Despite lacking enzymatic activity, these proteins serve as scaffolds for organizing macromolecular complexes and recruiting other proteins for proper localization during molecular signaling. Adaptor proteins harbor diverse protein-binding domains that link protein partners, enable the assembly of larger signaling complexes, and mediate molecular interactions. In human cells, adaptor proteins are classified into two types: signal transducing adaptor proteins (STAPs) and vesicular transport adaptor proteins.

Functions of Adaptor Proteins

STAPs are auxiliary to key proteins in signal transduction pathways, facilitating the assembly of larger signaling complexes. These proteins, such as MYD88, Grb2, and SHC1, lack intrinsic enzymatic activity but contain protein-binding modules that mediate specific protein-protein interactions. The specificity of signal transduction frequently depends on the assembly of signaling components into transient active complexes, typically initiated by an activating signal like the binding of a growth factor to its receptor.

Fig.1 Role of adaptor proteins in cellular internalization.¹

Adaptor proteins involved in vesicular transport play a critical role in organizing complexes that enable the movement of molecules between different compartments within cells. These complexes ensure the proper cargo molecules are concentrated in vesicles that bud from one organelle and travel to another, where they deliver the cargo. The clathrin-coated vesicle (CCV) is the most well-characterized type. Defects in components of these complexes are associated with various human ailments, including Parkinson's disease.

• Signal Transmission: Adaptor proteins are pivotal in transmitting signals from activated receptors or enzymes to downstream signaling molecules;
• Protein Sorting and Localization: Adaptor proteins direct proteins to specific cellular compartments by interacting with sorting signals and components involved in vesicle transport and membrane fusion;
• Facilitating Protein-Protein Interactions: Adaptor proteins utilize protein interaction domains to facilitate the assembly of multi-protein complexes, enabling diverse cellular processes;
• Modulating Membrane Dynamics: Adaptor proteins participate in membrane remodeling processes;
• Ubiquitin-Mediated Protein Turnover: Adaptor proteins facilitate the recognition and targeting of proteins for degradation through the ubiquitin-proteasome system.

Key Adaptor Proteins Targets

Amerigo Scientific provides a wide array of recombinant antibodies in diverse species, isotypes, and configurations. Should the specific antibody you are looking for not be available, our bespoke antibody engineering services are ready to fulfill your needs. Explore our catalog of antibodies related to adaptor proteins, or reach out to us for inquiries or quotes. We are enthusiastic to assist you.