Full Name: Thyroid Stimulating Hormone Receptor
BACKGROUND: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms: LGR3; CHNG1; hTSHR-I
Research Areas: Signal Transduction
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