Full Name: Integrin alpha 4 beta 7
BACKGROUND: Integrin α4β7 is a heterodimeric transmembrane protein expressed primarily on lymphocytes. It functions as a cell adhesion molecule by binding to its ligand MAdCAM-1 (Mucosal Addressin Cell Adhesion Molecule-1) expressed on endothelial cells in the gut. This interaction is crucial for the migration and homing of lymphocytes to mucosal tissues, playing a key role in gut immunity and inflammation.
Synonyms: Integrin α4β7; Integrin alpha 4 beta 7
Research Areas: Others
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