Full Name: TNF Receptor Superfamily Member 10a
BACKGROUND: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Synonyms: APO2; CD261; DR4; TRAILR-1; TRAILR1
Research Areas: Cell Biology
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