ROBO1

Full Name: Roundabout Guidance Receptor 1

BACKGROUND: Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: Roundabout Guidance Receptor 1; Deleted In U Twenty Twenty; DUTT1; Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila); Roundabout (Axon Guidance Receptor, Drosophila) Homolog 1; Roundabout, Axon Guidance Receptor, Homolog 1; Roundabout Homolog 1; H-Robo-1; SAX3