Cardiovascular diseases (CVDs) encompass a range of conditions that impact the heart and blood vessels, potentially causing serious health issues. These diseases can manifest in different forms such as heart attacks, strokes, and heart failure, and are known to be the leading cause of mortality globally. The interconnected nature of the cardiac and vascular systems underscores the importance of maintaining a healthy lifestyle and managing risk factors to prevent the onset of these potentially life-threatening conditions. Cardiovascular biology delves into the intricate mechanisms of cardiovascular function and dysfunction, with the ultimate goal of developing innovative therapies to combat heart disease. In recent years, Amerigo Scientific has focused on areas such as cardiovascular health, angiogenesis, coagulation, hypoxia, lipid metabolism, and various cardiovascular disorders.
Fig.1 Impact of prolonged hemodynamic pressure on the heart's function.1
The intricate coordination of cells in the cardiovascular system is vital for its proper function. Every cell within the cardiovascular system plays a crucial role in circulation, maintenance, and support of cardiovascular activity, perfusion, and system development.
Explore the intricate process of new blood vessel formation and growth as they navigate towards areas with inadequate blood supply. Angiogenesis is vital in embryonic development, tissue formation, pregnancy, wound healing, and tumor progression.
Delve into the intricacies of the proteolytic cascade leading to fibrin clot generation. This vital process is essential for hemostasis to prevent excessive blood loss following injury, yet it can pose risks in conditions like atherosclerosis, stroke, and deep vein thrombosis.
Hypoxia is a condition caused by low levels of oxygen in the body's tissues, often due to lung, heart, or altitude-related issues. Symptoms include breathing difficulties, confusion, and potential loss of consciousness. It is important to address hypoxia promptly to prevent any long-term damage to the body's organs.
Lipid metabolism is a complex biological process that involves the breakdown, synthesis, and storage of fats within the body. This process is essential for maintaining proper energy levels, regulating hormone production, and building cell membranes. Disruptions in lipid metabolism can lead to various health conditions, including hyperlipidemia (high levels of fats in the blood), which is a risk factor for heart disease and other cardiovascular problems. Proper regulation of lipid metabolism is important for overall health and well-being.
Cardiovascular diseases encompass a range of conditions impacting the heart and blood vessels, such as coronary artery disease, heart attack, stroke, heart valve issues, and peripheral vascular disease. Without effective management, these conditions can pose significant health risks and complications. These ailments collectively represent a significant global health burden, with cardiac vascular diseases ranking as the leading cause of mortality worldwide, responsible for approximately one-third of all deaths.
| Aorta disease and Marfan syndrome | Heart valve disease |
| Arrhythmias | Cardiomyopathy |
| Deep vein thrombosis and pulmonary embolism | Rheumatic heart disease |
| Coronary artery disease (narrowing of the arteries) | Peripheral vascular disease |
| Pericardial disease | Congenital heart disease |
| Heart attack | Stroke |
| Heart failure | Vascular disease (blood vessel disease) |
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