KLRC1

Full Name: Killer Cell Lectin Like Receptor C1

BACKGROUND: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Synonyms: Killer Cell Lectin Like Receptor C1; Killer Cell Lectin-Like Receptor Subfamily C, Member 1; CD159 Antigen-Like Family Member A; NKG2-1/B Activating NK Receptor; NKG2-A/B-Activating NK Receptor; NK Cell Receptor A; NKG2A; NKG2-A/NKG2-B Type II Integral Membrane Protein