GP6

Full Name: Glycoprotein VI Platelet

BACKGROUND: This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Synonyms: GP6; glycoprotein VI (platelet); GPIV; GPVI; BDPLT11; platelet glycoprotein VI; glycoprotein 6