Full Name: Gastric Inhibitory Polypeptide Receptor
BACKGROUND: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load.
Synonyms: GIP-R; PGQTL2; Glucose-Dependent Insulinotropic Polypeptide Receptor
Research Areas: Neuroscience
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