CCL17

Full Name: C-C Motif Chemokine Ligand 17

BACKGROUND: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.

Synonyms: CCL17; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17; Small-Inducible Cytokine A17; Thymus And Activation-Regulated Chemokine; ABCD-2; T Cell-Directed CC Chemokine; TARC; A-152E5.3