TPBG

Full Name: Trophoblast Glycoprotein

BACKGROUND: This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5&39; UTR results in multiple transcript variants that encode the same protein.

Synonyms: TPBG; M6P1; 5T4 Oncofetal Trophoblast Glycoprotein; Wnt-Activated Inhibitory Factor 1; Trophoblast Glycoprotein; 5T4AG; WAIF1; 5T4 Oncofetal Antigen; 5T4 Oncotrophoblast Glycoprotein; 5T4