Full Name: Glycosphingolipid globotriaosylceramide
BACKGROUND: Globotriaosylceramide is a ganglioside. It is also known as CD77, Gb3, and ceramide trihexoside. It is one of the few clusters of differentiation that is not a protein. It is formed by the alpha linkage of galactose to lactosylceramide catalyzed by A4GALT. It is metabolized by alpha-galactosidase, which hydrolyzes the terminal alpha linkage. Defects in the enzyme alpha-galactosidase lead to the build up of globotriaosylceramide, causing Fabry's disease. Globotriaosylceramide is also one of the targets of Shiga toxin, which is responsible for pathogenicity of enterohemorrhagic Escherichia coli (EHEC).
Synonyms: Gb3; Glycosphingolipid globotriaosylceramide; CD77
Research Areas: Glycobiology
Amerigo scientific offers a comprehensive range of antibodies target Gb3. Use the filter to find the Gb3 antibody that best fits your needs.
