Full Name: Sulfatase 2
BACKGROUND: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.
Synonyms: SULF2; Extracellular sulfatase Sulf-2; HSULF-2
Research Areas: Others
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