At Amerigo Scientific, we specialize in the development and production of high-quality glycobiology-related antibody products. These antibodies are designed to recognize specific glycosylation structures, allowing researchers to identify and characterize glycans.
Glycobiology is an interdisciplinary subject that aims to reveal the structure, synthesis, and function of glycoconjugates. Glycobiology is closely connected to many fields, such as biomedicine and biotechnology. Research subsets of glycobiology include carbohydrates, glycan formation and degradation, glycan recognition, and glycan function. Therefore, glycobiology often functions in conjunction with protein chemistry, cell biology, and developmental biology.
Structural characterization of glycans is a focus of glycobiology. As key components of glycoproteins, glycans are commonly found in blood, cell membranes, and other biological fluids. Glycans are crucial factors in the construction of complex multicellular organs. Furthermore, glycans are essential hubs mediating interactions between organisms, such as those between hosts and parasites. Therefore, the elucidation of the dynamic changes of glycans is conducive to understanding key biological processes in organisms.
Fig.1 Cell-free synthetic glycobiology systems.1
To date, aberrant glycosylation is present in almost all tumor cells. Tumor associated carbohydrate antigen (TACA) is a crucial compound that distinguishes cancer cells from normal cells. Differences in patient survival have been reported to be closely linked to TACA expression. In addition, TACA is a key factor in inducing invasiveness and metastasis. Therefore, TACA is also the focus of glycobiology research.
Cell surface glycolipids and glycoproteins provide receptor sites for bacteria and viruses, so abnormal cell surface glycosylation is closely linked to bacterial and viral infections. In rheumatic diseases, abnormal protein glycosylation is involved in the inflammatory process. In addition, altered glycosylation patterns are also critical factors in immune-related diseases. At present, abnormal glycosylation modifications in autoimmune diseases have gradually emerged as attractive markers for diagnosis and prognosis. Therefore, revealing the role of glycans in diseases opens up new prospects for the development of corresponding sugar therapies.
Glycosylation is one of the most prevalent modifications in biological systems. Glycobiological analysis is critical to many areas of research. However, glycoproteins and other glycoconjugates have diverse structures that are impossible to predict from genetic information alone. Therefore, appropriate strategies and tools are urgently needed to accomplish this task. Mass spectrometry as well as specialized tools such as tags, endo- and exonucleases, and biological reagents are available at Amerigo Scientific. Our diverse tools and strategies can power your glycobiology characterization.
In the rapidly evolving field of glycobiology, having the right tools and antibodies is crucial for making groundbreaking discoveries. At Amerigo Scientific, we are committed to providing researchers with high-quality, reliable, and versatile glycobiology-related antibody products. If you encounter any challenges or questions in your glycobiology research, please our scientists today for appropriate advice and feasible solutions.
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