Lineage specification refers to the process by which pluripotent cells develop toward a defined cell fate in a specific organism. During development, progenitor expansion, lineage assignment, and differentiation programs all require strict regulation. Therefore, lineage specification allows the generation of the appropriate number of cell types to achieve the correct tissue size and function. Understanding lineage assignment and specialization in an organism will contribute to understanding the origin of diseases and may provide a theoretical basis for the discovery of new treatments. Here, we summarize the lineage specification resources so that you can find new solutions faster.
Currently, similarities as well as species-dependent differences in preimplantation development are emerging as the focus of embryo analysis. In general, lineage-specific transcriptional networks are conserved, but the signaling pathways involved in lineage specification may be diverse. It is noteworthy that the relative importance of these signaling pathways may evolve in different species to facilitate the construction of key lineage-specific networks.
Fig.1 Classical hematopoietic tree.1, 2
The Wnt/β-catenin signaling pathway has been reported to be involved in the self-renewal and pluripotency of mouse and human embryonic stem (ES) cells. In addition, the Wnt signaling pathway may cross-link with other pathways to regulate downstream targets and thereby exert specific functions at different developmental stages.
The NFAT pathway plays a critical function in regulating early lineage specification. NFAT-Src-mediated epithelial-mesenchymal transition (EMT) has been reported to be a key hub for lineage specification. Studies have revealed that NFAT signaling cooperates with Ras-Erk-AP-1 to activate Src and initiate lineage specification in mouse embryonic stem cells (ESCs).
Hippo signaling pathways are involved in the regulation of many biological processes, including cell proliferation, lineage specification, wound healing, and mechanosensing. Furthermore, The Hippo signaling pathway is also a key regulatory factor in maintaining the self-renewal, proliferation, and differentiation of endogenous adult stem cells in various tissues.
Understanding lineage specialization in humans contributes to understanding the origins of human diseases, which also provides new ideas for finding new treatments. We have grouped lineage specification resources here to provide you with faster access to information in this field. For more details, please .
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