SYK

Full Name: Spleen Associated Tyrosine Kinase

BACKGROUND: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas.

Synonyms: Spleen Associated Tyrosine Kinase; p72-Syk