TREM1

Full Name: Triggering Receptor Expressed On Myeloid Cells 1

BACKGROUND: This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Synonyms: TREM1; triggering receptor expressed on myeloid cells 1; CD354; TREM-1; triggering-receptor TREM1