LASV GPC

Full Name: Pre-glycoprotein polyprotein GP complex

BACKGROUND: The glycoprotein complex (GPC) is the only viral protein on the surface of LASV and presents the sole target for neutralizing antibodies (NAbs).The GPC is expressed as a single polypeptide precursor before being proteolytically processed by signal peptidase (SPase) followed by site-1 protease (S1P). In its mature, native form, GPC is a trimer of heterotrimers comprised of the receptor-engaging subunit GP1; the transmembrane-spanning subunit GP2, which contains the GPC’s fusion peptide at its N terminus; and the stable signal peptide (SSP), which remains non-covalently complexed near the membrane-proximal region of GP2 post-cleavage.

Synonyms: GPC; LASV GPC; Glycoprotein Complex; Pre-glycoprotein polyprotein GP complex