Depletion Antibody Products

Amerigo Scientific provides a diverse selection of depletion antibodies targeting surface proteins and cytokines, facilitating in vivo studies focusing on cell-specific depletion. Our commitment to quality ensures reliable results, enabling researchers to generate publication-grade data.

Overview of Depletion Antibodies

Natural depletion, as observed in conditions such as HIV infection, or induced depletion for therapeutic interventions, underscores the widespread use of in vivo experiments aimed at selectively removing specific cell types to elucidate their roles in diverse immunological processes and diseases. These antibodies are designed for in vivo applications where the injected depletion antibody targets and eliminates a specific cell type. Such experiments are valuable for validating and extending findings from genetic knockout mouse models or for elucidating the direct biological relevance of certain cell types. These antibodies facilitate cell elimination through mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC).

Fig.1 Mechanism of action of cell-depleting therapeutic IgG antibodies in multiple sclerosis.¹

Advantages of Depletion Antibodies in Amerigo Scientific

• Enhanced Safety: These antibodies are engineered to exhibit improved safety profiles and reduced toxicity, thereby minimizing potential adverse effects.
• Batch-to-Batch Reproducibility: These antibodies display remarkable consistency across different production batches, ensuring reliable performance.
• High Receptor Binding Affinity and Specificity: Our products are designed to bind with exceptional affinity and specificity to target receptors, guaranteeing precise and effective therapeutic action.
• High Sensitivity: These antibodies are highly sensitive in detecting and binding to target receptors, thereby enhancing their effectiveness.
• High Purity: Manufactured to high purity standards, these antibodies ensure both safety and efficacy in clinical applications.

Antibodies Categorized by Applications

Amerigo Scientific has successfully developed a broad spectrum of immune cell-specific depletion antibodies targeting various molecules. For additional details and to explore opportunities for aligning with your research objectives, please contact us.