Amerigo Scientific is dedicated to providing innovative Fc engineering antibody products designed to enhance therapeutic efficacy and versatility. Our portfolio includes Fc-silenced antibodies, engineered to minimize immune effector functions for improved safety profiles, and non-fucosylated antibodies, which enhance ADCC activity for greater efficacy in targeting and eliminating cells.
The fragment crystallizable region (Fc) of the antibody plays a vital role in the immune response, as it can interact with cell surface receptors called Fc receptors and some proteins of the immune system. Changes in this region can dramatically influence the antibody function. Antibody Fc engineering involves the use of biotechnological strategies to create enhanced and optimized antibodies. This Fc engineering can modify and improve the characteristics of antibodies to enhance their properties like stability, effector function, half-life, and safety.
Fig.1 Enhancement of Fc-effector functions by Fc-engineering.1
Site-directed mutagenesis involves the alteration of the antibody's amino acid sequence at specific sites. Our scientists have a deep understanding of the relationship between the antibody structure and its function. By using site-directed mutagenesis, we construct modified or tailored antibodies with specific characteristics or features. Our Fc-engineering services include designing, constructing, expressing, and testing these genetically modified antibodies.
Glycosylation, the addition or removal of sugar molecules, directly affects the function of an antibody. By controlling this process, the antibody can be tailored to enhance its efficacy or decrease its immunogenicity. Our team works to manipulate and optimize the glycosylation pathways in cells. Our glycoengineering services include the design and production of antibodies with specific glycosylation, analysis of antibody glycosylation, and assessment of the impact of altered glycosylation on the function of antibodies.
Amerigo Scientific is dedicated to offering high-quality products in the area of antibody research and development. We proudly present our range of advanced Fc-engineered antibodies. Our company provides two distinct types of Fc-engineered antibodies: Fc-silenced antibodies and non-fucosylated antibodies. These antibodies have been precisely engineered and validated for quality – promising optimal performance in any given suitable application.
These antibodies have been precisely engineered to suppress their Fc region functionality, thereby substantially reducing their ability to trigger unwanted immune responses. Our Fc-silenced antibodies have shown robust performance in numerous applications, providing a versatile solution for researchers seeking reliable and repeatable results.
These specialized antibodies have been modified to remove the fucose sugar, leading to an increased affinity for Fc receptors on immune cells. This action enhances antibody-dependent cellular cytotoxicity (ADCC) activity, making non-fucosylated antibodies valuable in the study and potential treatment of various diseases.
Amerigo Scientific, a leader in Fc engineering solutions, is committed to offering specialized Fc engineering antibody products designed to meet the diverse needs of cutting-edge research and therapeutic development. Explore our catalog to find the Fc engineering antibodies that suit your innovative research needs.
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